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首页> 外文期刊>Pharmacogenomics >Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.
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Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.

机译：BDNF和NTRK2基因多态性与预防性锂反应在双相型患者中的关联研究。

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The neuroplasticity hypothesis of bipolar disorder indicates that the BDNF/Trk signaling pathway is associated with the pathogenesis of this illness and treatment with mood stabilizers, such as lithium. This paper describes a relationship between response to lithium prophylaxis and polymorphisms of two functionally connected genes: BDNF and NTRK2, in bipolar illness. Analyses of four SNPs of the BDNF gene (rs2030324, rs988748, rs6265 [Val66Met]and rs2203877) and three of the NTRK2 gene (rs1187326, rs2289656, rs1187327) were performed in the 108 bipolar patients, classified as excellent responders (23%), partial responders (51%) and nonresponders (26%) to lithium. An association of C/G (rs988748) and G/A (rs6265) polymorphisms of the BDNF gene with a degree of prophylactic lithium response were found. No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes.
机译：双相情感障碍的神经可塑性假设表明，BDNF / Trk信号通路与该疾病的发病机理以及用情绪稳定剂（如锂）进行治疗有关。本文描述了在双相性疾病中对锂预防的反应与两个功能相关基因（BDNF和NTRK2）的多态性之间的关系。在108名双极患者中对BDNF基因的四个SNP（rs2030324，rs988748，rs6265 [Val66Met]和rs2203877）和三个NTRK2基因（rs1187326，rs2289656，rs1187327）进行了分析，这些患者被分类为优秀应答者（23％），对锂的部分响应者（51％）和无响应者（26％）。发现BDNF基因的C / G（rs988748）和G / A（rs6265）多态性与预防性锂反应的程度相关。 NTRK2基因的多态性与锂反应没有关联，BDNF和NTRK2基因的相互作用也没有。

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