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Developmental and pediatric pharmacogenomics.

机译：发育和儿科药物基因组学。

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Children, as well as adults, should benefit from the discoveries of the genomic era. Many diseases with complex etiologies originate during childhood (e.g., asthma, autism, attention deficit/hyperactivity disorder, epilepsy and juvenile rheumatoid arthritis) and persist into adulthood. Attempts to better understand the genetic basis of age-specific disease processes requires an appreciation that the period of human development encompasses the prenatal period through adolescence, and is a rapidly changing, dynamic process. As a result, pharmacologic modulation of developing gene networks may have unintended and unanticipated consequences that do not become apparent or relevant until later in life. Thus, there is considerable potential for large-scale pharmacogenomic technologies to impact the development and utilization of new therapeutic strategies in children.
机译：儿童和成年人都应受益于基因组时代的发现。许多病因复杂的疾病起源于儿童时期（例如哮喘，自闭症，注意力缺陷/多动障碍，癫痫病和青少年类风湿性关节炎），并持续到成年期。试图更好地理解特定年龄疾病过程的遗传基础，需要认识到人类发展时期包括青春期之前的产前时期，并且是一个快速变化的动态过程。结果，正在发展的基因网络的药理调节可能会产生意想不到的后果，直到生命的后期才变得明显或相关。因此，大规模药物基因组学技术有很大的潜力影响儿童新治疗策略的开发和利用。

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