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The pharmacogenetics of opioid therapy in the management of postpartum pain: a systematic review

机译：阿片类药物治疗产后疼痛的药物遗传学：系统评价

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Aims: Opioids are commonly prescribed for postpartum pain. Yet, providing adequate pain relief, while ensuring that the mother and her breastfeeding infant are protected from adverse events can be challenging. The objective of this systematic review was to identify the role of opioid pharmacogenetics in analgesia and adverse events among patients being treated for postpartum pain, along with their breastfeeding infants. Methods: A comprehensive search of the literature was conducted in seven databases on June 3-4, 2015. Two reviewers independently screened studies for eligibility, extracted data and evaluated study quality using the Newcastle-Ottawa Scale. Results: Among the 2082 papers retrieved from the search, 17 were included in the review. These 17 papers consisted of various study designs, opioids, polymorphisms and patient outcomes. This systematic review reveals that CYP2D6, OPRM1 A118G, UGT2B7 C802T and ABCB1 G2677AT may contribute to postpartum analgesia or adverse events. Conclusion: These findings may assist in personalizing care for patients receiving opioids during the postpartum period.
机译：目的：阿片类药物通常用于产后疼痛。然而，在确保母亲和母乳喂养的婴儿免受不良事件影响的同时，提供足够的疼痛缓解可能是具有挑战性的。这项系统评价的目的是确定在接受产后疼痛治疗的患者及其母乳喂养婴儿中，阿片类药物药理遗传学在镇痛和不良事件中的作用。方法：2015年6月3-4日，在7个数据库中对文献进行了全面检索。两名审阅者使用纽卡斯尔-渥太华量表独立筛选研究的资格，提取数据并评估研究质量。结果：在检索到的2082篇论文中，有17篇被纳入评论。这17篇论文由各种研究设计，阿片类药物，多态性和患者预后组成。该系统评价显示CYP2D6，OPRM1 A118G，UGT2B7 C802T和ABCB1 G2677AT可能有助于产后镇痛或不良事件。结论：这些发现可能有助于在产后期间对接受阿片类药物的患者进行个性化护理。

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