A quantitative model of bacterial mismatch repair as applied to studying induced mutagenesis

Belov O.V.; Chuluunbaatar O.; Kapralov M.I.; Sweilam N.H.

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A quantitative model of bacterial mismatch repair as applied to studying induced mutagenesis

机译：细菌错配修复的定量模型用于研究诱变

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The paper presents a mathematical model of the DNA mismatch repair system in Escherichia coli bacterial cells. The key pathways of this repair mechanism were simulated on the basis of modern experimental data. We have modelled in detail five main pathways of DNA misincorporation removal with different DNA exonucleases. Here we demonstrate an application of the model to problems of radiation-induced mutagenesis.

机译：该论文提出了大肠杆菌细菌细胞中DNA错配修复系统的数学模型。在现代实验数据的基础上模拟了这种修复机制的关键途径。我们已经用不同的DNA外切核酸酶详细模拟了DNA错掺去除的五个主要途径。在这里，我们演示了该模型在辐射诱导诱变问题中的应用。

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《Physics of particles and nuclei letters》 |2013年第6期|共10页
作者
Belov O.V.; Chuluunbaatar O.; Kapralov M.I.; Sweilam N.H.;
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原文格式 PDF
正文语种 eng
中图分类粒子物理学;
关键词
bacterial mismatch; mutagenesis; radiation-induced;

机译：细菌错配;诱变;辐射诱导;

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1. A quantitative model of bacterial mismatch repair as applied to studying induced mutagenesis [J] . Belov O.V., Chuluunbaatar O., Kapralov M.I., Physics of particles and nuclei letters . 2013,第6期

机译：细菌错配修复的定量模型用于研究诱变
2. Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells [J] . Bugay Aleksandr N., Krasavin Evgeny A., Parkhomenko Aleksandr Yu., Journal of Theoretical Biology . 2015,第Null期

机译：建模的核苷酸切除修复及其对细菌细胞中SOS反应过程中紫外线诱导的诱变的影响
3. Roles of Endonuclease V, Uracil-DNA Glycosylase, and Mismatch Repair in Bacillus subtilis DNA Base-Deamination-Induced Mutagenesis [J] . Karina López-Olmos, Martha P. Hernández, Jorge A. Contreras-Gardu?o, Journal of bacteriology . 2012,第2期

机译：核酸内切酶V，尿嘧啶DNA糖基化酶和错配修复在枯草芽孢杆菌DNA碱基脱氨诱导诱变中的作用
4. A Conceptual Modeling Framework for the Study of DNA Mismatch Repair Pathway to Improve Therapeutic Gain in Cancer Treatment [C] . Evren Gurkan, Jane E. Schupp, Timothy J. Kinsella, IEEE/NIH Life Science Systems and Applications Workshop . 2007

机译：DNA错配修复途径研究概念建模框架，提高癌症治疗治疗增益
5. Evaluation of the accuracy of quantitative models in predicting Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) mutations in a population-based sample of early-onset colorectal cancer patients [D] . Carpiniello, Lauren 2007

机译：在以人群为基础的早发性大肠癌患者样本中预测定量模型预测Lynch综合征（遗传性非息肉病性大肠直肠癌，DNA失配修复缺陷）的准确性
6. Roles of Endonuclease V Uracil-DNA Glycosylase and Mismatch Repair in Bacillus subtilis DNA Base-Deamination-Induced Mutagenesis [O] . Karina López-Olmos, Martha P. Hernández, Jorge A. Contreras-Garduño, 2012

机译：核酸内切酶V尿嘧啶-DNA糖基化酶和错配修复在枯草芽孢杆菌DNA碱基脱氨诱导诱变中的作用。
7. Roles of Endonuclease V, Uracil-DNA Glycosylase, and Mismatch Repair in Bacillus subtilis DNA Base-Deamination-Induced Mutagenesis [O] . López-Olmos, Karina, Hernández, Martha P., Contreras-Garduño, Jorge A., 2011

机译：核酸内切酶V，尿嘧啶-DNA糖基化酶和错配修复在枯草芽孢杆菌DNA碱基脱氨诱导诱变中的作用。

A quantitative model of bacterial mismatch repair as applied to studying induced mutagenesis

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