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首页> 外文期刊>Pigment cell research >Relationship between skin response to ultraviolet exposure and skin color type
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Relationship between skin response to ultraviolet exposure and skin color type

机译：皮肤对紫外线照射的反应与肤色类型的关系

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摘要

Sun exposure is responsible for detrimental damage ranging from sunburn to photoaging and skin cancer. This damage is likely to be influenced by constitutive pigmentation. The relationship between ultraviolet (UV) sensitivity and skin color type was analyzed on 42 ex vivo skin samples objectively classified from light to dark skin, based on their values of individual typology angle (ITA) determined by colorimetric parameters. The biologically efficient dose (BED) was determined for each sample by quantifying sunburn cells after exposure to increasing doses of UV solar-simulated radiation. Typical UV-induced biologic markers, other than erythema, such as DNA damage, apoptosis and p53 accumulation, were analyzed. A statistically significant correlation was found between ITA and BED and, ITA and DNA damage. Interestingly, DNA lesions were distributed throughout the whole epidermal layers and the uppermost dermal cells in light, intermediate and tanned skin while they were restricted to suprabasal epidermal layers in brown or dark skin. Our data support, at the cellular level, the relationship between UV sensitivity and skin color type. They emphasize the impact of DNA damage accumulation in basal layer in relation to the prevalence of skin cancer.
机译：暴露于阳光下会造成从晒伤到光老化和皮肤癌的有害损害。这种损害很可能受到本构色素沉着的影响。基于42个从比色参数确定的个体类型角（ITA）值，对42个从浅色皮肤到深色皮肤客观分类的离体皮肤样本分析了紫外线（UV）敏感性与肤色类型之间的关系。在暴露于增加剂量的UV太阳模拟辐射后，通过量化晒伤细胞，确定每个样品的生物有效剂量（BED）。除红斑外，还分析了典型的紫外线诱导的生物标志物，例如DNA损伤，凋亡和p53积累。发现ITA和BED以及ITA和DNA损伤之间存在统计学上的显着相关性。有趣的是，DNA损伤分布在浅色，中性和晒黑皮肤的整个表皮层和最上层真皮细胞中，而它们仅限于棕色或深色皮肤的基底上表皮层。我们的数据在细胞水平上支持紫外线敏感性和肤色类型之间的关系。他们强调了DNA损伤在基底层积累与皮肤癌患病率的关系。

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