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Evaluation of melanin-related metabolites as markers of solar ultraviolet-B radiation

机译：黑色素相关代谢物作为太阳紫外线B辐射的标志物的评估

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摘要

Ultraviolet-B (UVB) radiation due sunlight can result in sunburns and/or suntans. Sunburn occurs only several hours after solar UVB radiation, while a suntan requires several days to several weeks to develop. In the present study, we measured serum and urine levels of melanin-related metabolites, 5-S-cysteinyldopa (5-S-CD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C), in nine subjects exposed to normal sunlight over the course of 12 months. We collected samples in the middle of each month and examined the variation of the markers, the correlation between them, and their correlation with solar UVB radiation. Those markers exhibited a seasonal variation with lower values in the winter and higher values in the summer. Levels of 5-S-CD and 6H5MI2C in the serum showed 48% and 54% increases in the summer compared with those in the winter, respectively. Comparison of 5-S-CD in the serum and urine showed the highest correlation (r(2) = 0.344), followed by the pair of 5-S-CD and 6H5MI2C in the serum. Levels of 5-S-CD in the serum showed the highest correlation (r(2) = 0.729) with the mean solar UVB radiation during the first 10 d of the month, while 6H5MI2C in the serum was highly correlated (r(2) = 0.483) with solar UVB radiation during the previous month. Levels of 5-S-CD and 6H5MI2C in the serum appear to reflect the degrees of skin injury and pigmentation in the skin, respectively.
机译：日光引起的紫外线B（UVB）辐射可导致晒伤和/或晒黑。日光UVB辐射仅在数小时后发生晒伤，而晒黑需要几天到几周才能发育。在本研究中，我们在9名暴露的受试者中测量了血清和尿液中与黑色素相关的代谢物，5-S-半胱氨酰多巴（5-S-CD）和6-羟基-5-甲氧基吲哚-2-羧酸（6H5MI2C）在12个月内保持正常的阳光照射。我们在每个月中旬收集样本，并检查标记的变化，它们之间的相关性以及它们与太阳UVB辐射的相关性。这些标志物表现出季节变化，冬季较低，夏季较高。与冬季相比，夏季的血清5-S-CD和6H5MI2C水平分别增加了48％和54％。血清和尿液中5-S-CD的比较显示最高相关性（r（2）= 0.344），其次是血清中的5-S-CD和6H5MI2C对。血清中5-S-CD的水平与该月前10天的平均太阳UVB辐射显示最高的相关性（r（2）= 0.729），而血清中的6H5MI2C高度相关（r（2） = 0.483），并且在上个月有太阳UVB辐射。血清中5-S-CD和6H5MI2C的水平似乎分别反映了皮肤损伤和皮肤色素沉着的程度。

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