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首页> 外文期刊>Pigment cell research >The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes
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The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes

机译：片状突变影响小鼠黑素细胞中黑素体的形态和成熟

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摘要

The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase in melanocytes and to reduce the melanin content in skin, hairs and eyes. Although the melanosomes in slaty melanocytes are reported to be eumelanosome-like, detailed melanosome biogenesis is not well studied. To address this point, melanosomes in neonatal epidermal melanocytes from wild-type (Dct(+)/Dct(+)) mice at the slaty locus as well as its congenic mouse mutant (Dct(slt)/Dct(slt)) in serum-free primary culture were observed under the electron microscope. Wild-type melanocytes possessed exclusively elliptical melanosomes with internal longitudinal structures, whereas in mutant melanocytes, numerous spherical melanosomes with globular depositions of pigment and elliptical melanosomes as well as mixed type of the two melanosomes were observed. Mature stage IV melanosomes were greatly decreased in mutant melanocytes, whereas immature stage III melanosomes were more numerous than in wild-type melanocytes. These results suggest that the slaty mutation affects the morphology and maturation of melanosomes in mouse melanocytes.
机译：已知板岩状（Dct（slt））突变可降低黑素细胞中多巴色素互变异构酶的活性，并降低皮肤，头发和眼睛中黑色素的含量。尽管据报道板状黑素细胞中的黑素体是类黑素体，但详细的黑素体生物发生还没有得到很好的研究。为了解决这一点，来自板状基因座的野生型（Dct（+）/ Dct（+））小鼠及其血清中的同系小鼠突变体（Dct（slt）/ Dct（slt））的新生儿表皮黑素细胞中的黑素体在电子显微镜下观察到无游离的原代培养物。野生型黑素细胞仅具有具有内部纵向结构的椭圆形黑素体，而在突变黑素细胞中，观察到许多球形的黑素体，其具有球状沉积的色素和椭圆形黑素体，以及两种黑素体的混合类型。在突变的黑素细胞中，成熟的IV期黑素体大大减少，而未成熟的III期黑素体比野生型黑素细胞多。这些结果表明，板岩状突变影响小鼠黑素细胞中黑素体的形态和成熟。

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