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首页> 外文期刊>Pigment cell research >Melanin in human irides of different color and age of donors
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Melanin in human irides of different color and age of donors

机译：供体颜色和年龄不同的人体内的黑色素

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Melanin is the main chromophore of the human iris. This pigment is considered to be the most important factor that determines the color of the irides. Previous studies based mainly on chemical degradation methods showed that brown irides contain more melanin than blue ones. In our study, we used electron spin resonance (ESR) spectroscopy to detect and characterize melanin free radical centers and associated iron in human irides. Based on this method, we determined the amount of melanin in the irides and the relative content of iron in iridial melanin as a function of their color, shade, and the age of their donors. Chemical degradation of iridial homogenates enabled us to characterize the structure of eumelanin and determine the content of pheomelanin present in human and bovine irides. The ESR amplitude, the normalized intensity obtained by double integration of the ESR signal of melanin, and the content of the pigment in the irides depended on color and shade of the eyes being 40% higher in the brown group of the irides compared with all other groups. On the other hand, the relative iron content normalized to the melanin content in light blue irides showed a small decrease with age of donors. Melanin in human and bovine irides was mostly composed of eumelanin, and pheomelanin content was of the order of a few percent. Although some differences in the structure of eumelanin present in the human and bovine irides are possible, the results obtained in this study suggest that human irides contain eumelanin with very similar chemical properties.
机译：黑色素是人类虹膜的主要发色团。该颜料被认为是决定铱的颜色的最重要因素。先前主要基于化学降解方法的研究表明，棕色的氮化物比蓝色的含有更多的黑色素。在我们的研究中，我们使用电子自旋共振（ESR）光谱来检测和表征人类铱中的黑色素自由基中心和相关铁。基于此方法，我们确定了铱离子中黑色素的含量以及铱黑色素中铁的相对含量随其颜色，阴影和供体年龄的变化而变化。虹膜匀浆的化学降解使我们能够表征Eumelanin的结构，并确定人和牛iride中pheomelanin的含量。 ESR振幅，通过黑色素的ESR信号的两次积分获得的归一化强度以及虹彩物中的色素含量取决于虹彩的棕色组中眼睛的颜色和阴影是否比其他所有彩眼高40％组。另一方面，归一化为浅蓝色铱化物中黑色素含量的相对铁含量随供体的年龄而降低。人和牛血清中的黑色素主要由Eumelanin组成，pheomelanin含量约为百分之几。尽管人和牛iride中存在的eumelanin结构可能存在某些差异，但本研究获得的结果表明，人iride中含有具有非常相似化学性质的eumelanin。

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