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首页> 外文期刊>Biomaterials >Blood vessel formation after soft-tissue implantation of hyaluronan-based hydrogel supplemented with copper ions.
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Blood vessel formation after soft-tissue implantation of hyaluronan-based hydrogel supplemented with copper ions.

机译：透明质酸基水凝胶补充铜离子的软组织植入后血管的形成。

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摘要

The possibility of ameliorating bone healing of implanted bone allografts is a field of great interest. Early vascular invasion is a key factor in bone allograft incorporation. It is well known that copper ions (Cu(2+)) show a proangiogenic action favouring the development of new vessels. In this work a hyaluronan based 50% hydrogel (Hyal-50%) was enriched with (Cu(2+)) and its proangiogenic activity was evaluated. Fifteen Sprague Dawley female rats were submitted to the subcutaneous implantation of Hyal-50%, freeze-dried bone allografts, Hyal-50%-Cu(2+), freeze-dried bone allografts plus Hyal-50% and freeze-dried bone allografts plus Hyal-50%-Cu(2+). One month later, histomorphometric analysis evidenced the presence of a fibrous-reactive capsule around all specimens showing significant differences among groups (p<0.0005). The highest thickness of the fibrous capsule was found around the freeze-dried bone implants (p<0.05); as well as the Hyal-50%-Cu(2+) plus freeze-dried bone (15.2%, p<0.05) and Hyal 50% plus freeze-dried bone (21.4%, p<0.0005) implants showed a significant higher thickness compared with Hyal 50% and Hyal-50%-Cu(2+). Statistical analysis showed a significant (p<0.01) higher vascular density in Hyal- 50%-Cu(2+) and Hyal-50%-Cu(2+) plus freeze-dried bone group when compared to other groups. The present preliminary results suggest the advantages offered by the combined use of a well-known biocompatible and tissue healing promoting material (Hyal-50%) and a new technique that consists of stimulating tissue vascularization using Cu(2+) and that bone allograft incorporation may benefit from this technology.
机译：改善植入的同种异体骨的骨愈合的可能性是人们非常感兴趣的领域。早期血管浸润是同种异体骨植入的关键因素。众所周知，铜离子（Cu（2+））具有促血管生成作用，有利于新血管的发育。在这项工作中，一种基于透明质酸的50％水凝胶（Hyal-50％）富含（Cu（2+）），并评估了其促血管生成活性。将15只Sprague Dawley雌性大鼠皮下植入Hyal-50％，冻干的骨同种异体，Hyal-50％-Cu（2+），冻干的骨同种异体加Hyal-50％和冻干的同种异体加上Hyal-50％-Cu（2+）。一个月后，组织形态计量学分析表明，所有标本周围均存在纤维反应性包膜，显示各组之间存在显着差异（p <0.0005）。在冻干骨植入物周围发现纤维囊的最高厚度（p <0.05）;以及Hyal-50％-Cu（2+）加冻干骨（15.2％，p <0.05）和Hyal 50％-加冻干骨（21.4％，p <0.0005）植入物显示出明显更高的厚度与Hyal 50％和Hyal-50％-Cu（2+）相比。统计分析表明，与其他组相比，Hyal-50％-Cu（2+）和Hyal-50％-Cu（2+）加冻干骨组的血管密度显着（p <0.01）高。目前的初步结果表明，结合使用众所周知的生物相容性和组织愈合促进材料（Hyal-50％）和一项新技术，该技术包括使用Cu（2+）刺激组织血管形成和同种异体骨植入可能会受益于这项技术。

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