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首页> 外文期刊>Chemical Senses >Validation of Edible Taste Strips for Assessing PROP Taste Perception
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Validation of Edible Taste Strips for Assessing PROP Taste Perception

机译：验证可食用口味条以评估PROP口味知觉

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摘要

A novel delivery method is described that incorporates taste stimuli into edible strips for determining n-propylthiouracil (PROP) taster status. Edible strips that contained 400 or 600nanomoles of PROP were prepared for psychophysical studies. Using these strips, we measured taste intensity, taste hedonics, and taste quality responses in a sample of healthy volunteers (n = 118). Participants were also asked to assess a single NaCI strip, a quinine strip, 3 NaCI solutions, and 3 PROP solutions. All psychophysical data were subsequently analyzed as a function of TAS2R38 genotype. The use of PROP strips for distinguishing between individuals with at least 1 PAV allele and individuals with other genotypes was assessed and compared with the use of PROP solutions for making this same distinction. For the 2 PROP strips and PROP solutions, individuals who expressed at least 1 PAV allele could perceive the bitter taste of PROP. Individuals who expressed 2 AVI alleles responded similarly to 400nanomole PROP strips and blank strips. Furthermore, individuals with 2 AVI alleles responded to 0.032 and 0.32 mM PROP solutions at intensities that were similar to water, though intensity ratings to 3.2 mM PROP solution exceeded water. In general, those with at least 1 PAV allele rated the bitter taste of PROP as unpleasant in both delivery methods (strips or solutions). Psychophysical data from PROP strips and solutions were consistent with TAS2R38 genotype. These results support the validity of edible taste strips as a method for assessing PROP taste perception in humans.
机译：描述了一种新颖的递送方法，该方法将味觉刺激掺入可食条中以确定n-丙基硫氧嘧啶（PROP）味觉状态。准备包含400或600纳摩尔PROP的可食用试纸用于心理物理研究。使用这些试纸，我们在健康志愿者的样本（n = 118）中测量了味觉强度，味觉享乐和味觉质量反应。还要求参与者评估单个NaCl试纸，奎宁试纸，3种NaCl溶液和3种PROP溶液。随后根据TAS2R38基因型分析所有心理数据。评估了PROP条用于区分至少1个PAV等位基因的个体和其他基因型个体的用途，并与PROP溶液的使用作了相同的区分。对于2个PROP条和PROP解决方案，表达至少1个PAV等位基因的个人可能会感觉到PROP的苦味。表达2个AVI等位基因的个体对400纳摩尔PROP条和空白条的反应相似。此外，具有2个AVI等位基因的个体以与水相似的强度对0.032和0.32 mM PROP溶液做出反应，尽管对3.2 mM PROP溶液的强度等级超过了水。通常，那些具有至少1个PAV等位基因的人认为PROP的苦味在两种递送方法（条或溶液）中均不令人满意。来自PROP条和解决方案的心理数据与TAS2R38基因型一致。这些结果支持了可食用调味条作为评估人类PROP味道知觉的方法的有效性。

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