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首页> 外文期刊>Polimery >The effect of PAMAM dendrimers with amine or hydroxyl terminal groups on the bioadhesive properties of hydrogels with clotrimazole
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The effect of PAMAM dendrimers with amine or hydroxyl terminal groups on the bioadhesive properties of hydrogels with clotrimazole

机译：具有氨基或羟基端基的PAMAM树状聚合物对克霉唑水凝胶的生物粘附性能的影响

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Polyamidoamine dendrimers (PAMAM) belong to a relatively new class of polymers that are evaluated as efficient systems for drug delivery due to their nanosize range, ability to improve solubility, permeability and pharmacological activity of many drugs. In this study, the influence of PAMAM dendrimers of generation 2 (G2) and 3 (G3) with -NH2 or -OH terminal groups (PAMAM-NH2 and PAMAM-OH, respectively) on the bioadhesive properties, viscosity and yield stress of polyacrylic acid polymer hydrogels with clotrimazole was investigated. We show that the addition of PAMAM-NH2 dendrimers G2 and G3 into the hydrogel structures caused, in both cases, an about 2-fold decrease in viscosity of the hydrogels and a 1.3 and 1.4-fold decrease in the value of yield stress, respectively. We also found that PAMAM dendrimers with -NH2 terminal groups induced the highest decrease in the work of adhesion between hydrogels and the examined adhesive layers.
机译：聚酰胺基胺树枝状聚合物（PAMAM）属于一类相对较新的聚合物，由于其纳米尺寸范围，提高许多药物的溶解性，渗透性和药理活性的能力，因此被视为有效的药物输送系统。在这项研究中，第2代（G2）和第3代（G3）带有-NH2或-OH端基（分别为PAMAM-NH2和PAMAM-OH）的PAMAM树状聚合物对聚丙烯酸酯的生物粘附性能，粘度和屈服应力的影响研究了含克霉唑的酸性聚合物水凝胶。我们表明，在两种情况下，向水凝胶结构中添加PAMAM-NH2树枝状聚合物G2和G3均导致水凝胶粘度分别降低约2倍和屈服应力值分别降低1.3和1.4倍。我们还发现，带有-NH2末端基团的PAMAM树枝状聚合物在水凝胶与所检查的粘合剂层之间的粘合功降低最大。

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