...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Comparative studies on the cytotoxicity, cellular and nuclear uptake of a series of chloro gold(I) phosphine complexes
【24h】

Comparative studies on the cytotoxicity, cellular and nuclear uptake of a series of chloro gold(I) phosphine complexes

机译：一系列氯金（I）膦复合物的细胞毒性，细胞和核吸收的比较研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Gold(I) phosphine complexes have shown promising results as a novel class of anticancer drugs in a variety of biochemical and pharmacological investigations. Studies on pharmacokinetic properties of these species are rare. Here we report the results of a comparative study on the cytotoxicity, cellular and nuclear uptake of a series of chloro gold(I) phosphine complexes (Cl-Au-P(R)(3), R = Me, Et, tert-But, Ph) containing different ligands on the phosphor. Cellular and nuclear gold levels in HT-29 colon carcinoma and MCF-7 breast cancer cells were measured by electrothermal atomic absorption spectrometry. All studied complexes exhibited significant antiproliferative effects in both investigated cell lines. Cellular and nuclear gold levels were enhanced especially for Cl-Au-P(Ph)(3) indicating a positive influence of larger and more lipophilic substituents.
机译：在多种生化和药理研究中，金（I）膦复合物作为一类新型抗癌药物已显示出令人鼓舞的结果。这些物种的药代动力学特性研究很少。在这里，我们报告了一系列氯金（I）膦配合物（Cl-Au-P（R）（3），R = Me，Et，叔丁基）的细胞毒性，细胞和核吸收的比较研究结果。 ，Ph）在荧光粉上含有不同的配体。通过电热原子吸收光谱法测量HT-29结肠癌和MCF-7乳腺癌细胞的细胞和核金水平。所有研究的复合物在两种研究的细胞系中均表现出显着的抗增殖作用。细胞和核金水平特别是对于Cl-Au-P（Ph）（3）有所提高，表明更大和更多亲脂性取代基的积极影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号