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首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >New palladium(II) complexes of 3-methoxysalicylaldehyde-4(N)-substituted thiosemicarbazones: Synthesis, spectroscopy, X-ray crystallography and DNA/protein binding study
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New palladium(II) complexes of 3-methoxysalicylaldehyde-4(N)-substituted thiosemicarbazones: Synthesis, spectroscopy, X-ray crystallography and DNA/protein binding study

机译：3-甲氧基水杨醛-4（N）-取代的硫代半脲的新型钯（II）配合物：合成，光谱，X射线晶体学和DNA /蛋白质结合研究

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摘要

A series of 4(N)-substituted 3-methoxysalicylaldehyde thiosemicarbazone (H_2L1-H_2L4) were reacted with equimolar amount of [PdCl_2(AsPh_3)_2] in ethanol/dichloromethane medium. The new complexes have been characterized by various spectroscopic techniques. The structure determination of the complexes [Pd(H-Msal-mtsc)(AsPh_3)](2), [Pd(H-Msal-etsc)(AsPh_3)](3) and [Pd(Msal-ptsc)(AsPh_3)](4) by X-ray crystallography showed that the ligands H_2L2 and H_2L3 are coordinated as monobasic bidentate NS donor in the complexes 2 and 3 by forming a five member chelate ring. However, in the complex 4, the ligand H_2L4 bound to palladium as dibasic tridentate ONS donor by forming six and five member chelate rings. The binding ability of the palladium(II) precursor [PdCl_2(AsPh_3)_2], ligands (H_2L1-H_2L4) and their corresponding complexes (1-4) with calf-thymus DNA (CT DNA) has been examined by photophysical studies, which revealed that the complexes bound to DNA through intercalation mode. The protein binding studies have been monitored by quenching of tryptophan and tyrosine residues in the presence of compounds by taking bovine serum albumin (BSA) as a model protein and the mechanism of quenching was found as static. The binding study results showed that the new complexes 1-4 possess better binding affinity than the starting precursor and ligands (H_2L1-H_2L4).
机译：在乙醇/二氯甲烷介质中，将一系列4（N）取代的3-甲氧基水杨醛硫代半脲（H_2L1-H_2L4）与等摩尔量的[PdCl_2（AsPh_3）_2]反应。新络合物已通过各种光谱技术进行了表征。配合物[Pd（H-Msal-mtsc）（AsPh_3）]（2），[Pd（H-Msal-etsc）（AsPh_3）]（3）和[Pd（Msal-ptsc）（AsPh_3）的结构确定X射线晶体学]（4）显示，配位体H_2L2和H_2L3通过形成五元螯合环而作为配合物2和3中的一元二齿NS供体配位。然而，在配合物4中，配体H_2L4通过形成六个和五个成员的螯合环而作为二元三齿ONS供体与钯结合。通过光物理研究检查了钯（II）前体[PdCl_2（AsPh_3）_2]，配体（H_2L1-H_2L4）及其相应的配合物（1-4）与小牛胸腺DNA（CT DNA）的结合能力，揭示了复合物通过嵌入模式与DNA结合。通过以牛血清白蛋白（BSA）为模型蛋白，在化合物存在下，通过色氨酸和酪氨酸残基的淬灭来监测蛋白质结合研究，发现淬灭的机理是静态的。结合研究结果表明，新的配合物1-4具有比起始前体和配体（H_2L1-H_2L4）更好的结合亲和力。

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