Total synthesis of the core tetrasaccharide of Neisseria meningitidis lipopolysaccharide, a potential vaccine candidate for meningococcal diseases

You Yang; Christopher E. Martin; Peter H. Seeberger

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Total synthesis of the core tetrasaccharide of Neisseria meningitidis lipopolysaccharide, a potential vaccine candidate for meningococcal diseases

机译：脑膜炎奈瑟氏球菌脂多糖的核心四糖的全合成，这可能是脑膜炎球菌疾病的候选疫苗

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The first total synthesis of the core tetrasaccharide α-GlcNAc-(1→2)-α-Hep-(1→ 3)-α-Hep-(1→ 5)-α-Kdo of Neisseria meningitidis LPS is achieved in a convergent and stereocontrolled [2 + 2] approach, whereby heptose building blocks obtained by de novo synthesis were fine-tuned for the effective assembly of the 1 → 5 linked Hep-Kdo disaccharide. The synthetic strategy incorporates an a-linked spacer at the reducing end of the tetrasaccharide for use as a handle during subsequent conjugation to a carrier protein.

机译：脑膜炎奈瑟氏球菌LPS的核心四糖α-GlcNAc-（1→2）-α-Hep-（1→3）-α-Hep-（1→5）-α-Kdo的首次全合成和立体控制的[2 + 2]方法，其中微调了从头合成获得的庚糖结构单元，以有效组装1→5连接的Hep-Kdo二糖。合成策略在四糖的还原末端结合了一个a-连接的间隔基，用作随后与载体蛋白结合的手柄。

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《Chemical science》 |2012年第3期|共4页
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You Yang; Christopher E. Martin; Peter H. Seeberger;
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正文语种 eng
中图分类化学;
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1. Total synthesis of the core tetrasaccharide of Neisseria meningitidis lipopolysaccharide, a potential vaccine candidate for meningococcal diseases [J] . You Yang, Christopher E. Martin, Peter H. Seeberger Chemical science . 2012,第3期

机译：脑膜炎奈瑟氏球菌脂多糖的核心四糖的全合成，这可能是脑膜炎球菌疾病的候选疫苗
2. Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease [J] . Lisa K. McNeil, Robert J. Zagursky, Shuo L. Lin, Microbiological reviews . 2013,第2期

机译：H因子结合蛋白在脑膜炎奈瑟氏菌毒力中的作用及其作为广泛预防脑膜炎球菌疾病的疫苗候选者的潜力
3. Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures [J] . Jaekel Anne, Plested Joyce S, Hoe JClaire, Vaccine . 2008,第51期

机译：脑膜炎奈瑟氏球菌内脂脂质表位的天然人血清抗体可预防由表现出同源内核结构的分离株引起的浸润性脑膜炎球菌病
4. SYNTHESIS OF A NEISSERIA MENINGITIDIS SEROGROUP Y ANTIGEN FRAGMENT AND ITS 4-FLUORINATED ANALOGUE FOR FULLY SYNTHETIC VACCINE CANDIDATES [C] . S. Neidig, M. Reindl, M. Daum International Carbohydrate Symposium . 2018

机译：用于全合成疫苗候选的Neisseria meningitidis血清群抗原片段的合成抗原片段及其4氟化类似物
5. Characterization of the molecular epidemiology of Neisseria meningitidis and investigation of two potential risk factors associated with invasive meningococcal disease. [D] . Schmidt, Mark Andrew. 2009

机译：脑膜炎奈瑟氏菌的分子流行病学特征和与浸润性脑膜炎球菌病相关的两个潜在危险因素的研究。
6. Conjugation of meningococcal lipopolysaccharide R-type oligosaccharides to tetanus toxoid as route to a potential vaccine against group B Neisseria meningitidis. [O] . H J Jennings, C Lugowski, F E Ashton 1984

机译：脑膜炎球菌脂多糖R型寡糖与破伤风类毒素的缀合作为针对B组脑膜炎奈瑟氏球菌的潜在疫苗的途径。
7. Antigenic potential of a highly conserved Neisseria meningitidis lipopolysaccharide inner core structure defined by chemical synthesis [O] . Reinhardt, Anika, Yang, You, Claus, Heike, 2015

机译：化学合成确定的高度保守的脑膜炎奈瑟氏球菌脂多糖内部核心结构的抗原潜力
8. Noncovalent Complex Vaccine, Prepared with Detoxified Escherichia coli J5 (RcChemotype) Lipopolysaccharide and Neisseria meningitidis Group B Outer Membrane Protein, Produces Protective Antibodies against Gram-Negative Bacteremia [R] . Bhattacharjee, A. K., Opal, S. M., Taylor, R., 1996

机译：非共价复合疫苗，用解毒的大肠杆菌J5（RcChemotype）脂多糖和脑膜炎奈瑟菌B组外膜蛋白制备，产生针对革兰氏阴性菌血症的保护性抗体

Total synthesis of the core tetrasaccharide of Neisseria meningitidis lipopolysaccharide, a potential vaccine candidate for meningococcal diseases

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