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The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold

机译：动物源年龄对细胞外基质支架体内重塑特性的影响

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摘要

Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the age of the animal from which the ECM is derived. The present study compared the . in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source animal age. Scaffolds derived from younger animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response.
机译：由哺乳动物细胞外基质（ECM）组成的生物支架通常在各种临床前和临床应用中用于修复和重建受伤或缺失的组织。但是，结构和功能的结果差异很大。异种生物支架的一个重要变量是产生ECM的动物的年龄。本研究比较了。由年龄不同的猪收获的小肠粘膜下层（SIS）-ECM组成的生物支架的体内宿主反应和重塑结果。结果表明，由于动物源年龄，重塑特征存在明显差异。与从较老的动物衍生的支架相比，从较年轻的动物衍生的支架与更具建设性的，适合部位的组织重塑反应相关。此外，建设性重塑反应与占主导地位的M2巨噬细胞反应。

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