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Exercise in the treatment of major depression: A systematic review grading the quality of evidence

机译：在重度抑郁症的治疗中进行锻炼：对证据质量分级的系统评价

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Objective: To examine the quality of evidence for exercise in the treatment of major depression, comparing specific study types; aerobic exercise vs. antidepressants, aerobic exercise vs. any physical activity, and aerobic exercise as augmentation therapy to treatment as usual vs. treatment as usual. Methods: Electronic searches for randomized controlled studies, reporting on treatment outcome in adults with major depression confirmed by a clinical interview. Quality of evidence was assessed using the Grading and Recommendations Assessment, Development and Evaluation and an additional risk of bias-protocol. Results: Fourteen eligible studies were retrieved, of which nine had low risk of bias. We found moderate quality of evidence that aerobic exercise has no significant effect compared to antidepressants. We found moderate quality of evidence that aerobic exercise at a moderate to high intensity has no significant effect compared to other forms of physical activity. We found low quality of evidence that exercise as augmentation to treatment as usual has a small effect-depression scores were on average 0.44 of a standard deviation lower-compared to treatment as usual. Conclusion: In general, exercise appears to be beneficial in the treatment of depression when used in combination with medication. A significant issue that is not well addressed in previous studies is the risks associated with exercise. Further, this review indicates that aerobic exercise is not more effective than other types of physical activity, pointing to a need to further investigate active components.
机译：目的：通过比较特定的研究类型，检查运动疗法治疗重度抑郁症的证据质量;有氧运动与抗抑郁药，有氧运动与任何身体活动的对比，以及有氧运动作为常规治疗与常规治疗的增强疗法。方法：通过电子搜索进行随机对照研究，通过临床访谈证实成人重度抑郁症的治疗结果。证据的质量使用“分级和建议书评估，开发和评估”以及偏见协议的附加风险进行评估。结果：共检索到14篇合格研究，其中9篇有偏倚风险低。我们发现有中等质量的证据表明有氧运动与抗抑郁药相比没有明显的作用。我们发现中等质量的证据表明，与其他形式的体育锻炼相比，中等强度到高强度的有氧运动没有明显的影响。我们发现，证据表明，像往常一样增加锻炼作为常规治疗的效果抑郁评分较低，平均为标准差的0.44。结论：通常，运动与药物结合使用对抑郁症的治疗似乎有益。在以前的研究中没有很好解决的一个重要问题是与运动有关的风险。此外，该评论表明，有氧运动并不比其他类型的体育锻炼更有效，这表明需要进一步研究活性成分。

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