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Past, present and future in the field of polymeric reagents

机译：高分子试剂领域的过去，现在和未来

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I was fortunate to have had great scientists and excellent teachers who introduced me to the life of science. I learned much from Dr S. Patai about the general field of organic synthesis during my MSc studies (1951). Professor F. Katzir-Katchalsky inspired me during my PhD studies (late 1950s) with his research on the immobilization of enzymes, so that I look upon my contributions to the field of polymeric reagents as an extension of this concept. The main novel subjects dealt with in this article were the following. Novel analytical methods in the analyses of functional groups bound to insoluble heterogeneous systems, such as polymeric reagents. This includes the use of non-aqueous titrations and the USR. Polymers as donors in various electrophilic reactions have been introduced, including methods for efficient peptide synthesis. The concept of infinite dilution or concentration was introduced, using polymer-bound reagents. This was used in cyclization reactions and in the isolation of short-lived reactive intermediates. In collaboration with Professor Woodward, we introduced the photosensitive blocking groups, which later became a general and useful tool in field of synthetic organic chemistry, in photorelease of biologicially active molecules and in combinatorial chemistry of multipeptide syntheses and has extended today to DNA chips.
机译：我很幸运，有伟大的科学家和优秀的老师向我介绍了科学的生活。我在理学硕士课程中（1951年）从S. Patai博士那里学到了很多有关有机合成的一般领域的知识。 F. Katzir-Katchalsky教授在我的博士研究期间（1950年代后期）通过对酶固定化的研究启发了我，因此，我将自己在聚合试剂领域的贡献视为这一概念的扩展。本文涉及的主要小说主题如下。用于分析与不溶性异质系统（例如聚合试剂）结合的官能团的新型分析方法。这包括使用非水滴定法和USR。已经引入了在各种亲电反应中作为供体的聚合物，包括有效的肽合成方法。使用与聚合物结合的试剂，引入了无限稀释或浓缩的概念。将其用于环化反应和短寿命反应性中间体的分离。与伍德沃德教授合作，我们引入了光敏保护基团，该基团后来成为合成有机化学领域，生物活性分子的光释放以及多肽合成的组合化学领域的通用和有用工具，如今已扩展到DNA芯片。

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