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Responsive micelles and vesicles based on polypeptide diblock copolymers

机译：基于多肽二嵌段共聚物的响应性胶束和囊泡

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摘要

The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with a control size and shape. Results focusing on vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical application will be detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems that are able to form vesicles with narrow size distributions at basic and acidic pH going through an intermediate state of single polymer chains are presented. These nanoparticles are particularly interesting for encapsulation and delivery purposes at a controlled pH. Finally, surface self-assembly of micelles and vesicles will be shown as models for biological surfaces such as mucosal surfaces.
机译：提出了明确定义的基于多肽的二嵌段共聚物自组装成胶束和囊泡的自组装。多肽对pH和离子强度的刺激响应行为被用于产生具有控制大小和形状的刺激响应纳米颗粒。通过静态和动态光散射分析，UV圆二色性，NMR和小角度中子散射实验，将详细介绍针对从基于多肽的二嵌段共聚物中获得的，特别有望用于生物医学的囊泡的结果。还提出了能够在碱性和酸性pH下通过单个聚合物链的中间状态形成具有窄尺寸分布的囊泡的系统。这些纳米颗粒对于在受控pH下的包封和递送目的特别令人感兴趣。最后，胶束和囊泡的表面自组装将显示为生物表面（如粘膜表面）的模型。

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