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首页> 外文期刊>Biomolecular engineering >pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers.
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pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers.

机译：基于多肽二嵌段共聚物的pH响应胶束和囊泡纳米胶囊。

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摘要

The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with controlled size and shape. Results focusing on micelles and vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical applications are detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems able to form vesicles with a narrow size distribution at basic and acid pH going through a single molecule intermediate state are presented. These nanoparticles are particularly interesting for encapsulation and delivery purpose at a controlled pH.
机译：提出了明确定义的基于多肽的二嵌段共聚物自组装成胶束和囊泡的自组装。多肽对pH和离子强度的刺激响应行为用于产生具有受控大小和形状的刺激响应纳米颗粒。通过静态和动态光散射分析，UV圆二色性，NMR和小角度中子散射实验，详细描述了从基于多肽的二嵌段共聚物获得的，特别是有望用于生物医学的多肽和胶束得到的结果。还提出了能够形成在碱性和酸性pH下通过单个分子中间状态具有窄尺寸分布的囊泡的系统。这些纳米颗粒对于在受控pH下的包封和递送目的特别令人感兴趣。

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