...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemical Senses >Presynaptic Inhibition of Olfactory Sensory Neurons: New Mechanisms and Potential Functions
【24h】

Presynaptic Inhibition of Olfactory Sensory Neurons: New Mechanisms and Potential Functions

机译：嗅觉感觉神经元的突触前抑制：新机制和潜在功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Presynaptic inhibition is the suppression of neurotransmitter release from a neuron by inhibitory input onto its presynaptic terminal. In the olfactory system, the primary sensory afferents from the olfactory neuroepithelium to the brain's olfactory bulb are strongly modulated by a presynaptic inhibition that has been studied extensively in brain slices and in vivo. In rodents, this inhibition is mediated by γ-amino butyric acid (GABA) and dopamine released from bulbar interneurons. The specialized GABAergic circuit is now well understood to include a specific subset of GAD65-expressing periglomerular interneurons that stimulate presynaptic GABA_B receptors to reduce presynaptic calcium conductance. This inhibition is organized to permit the selective modulation of neurotransmitter release from specific populations of olfactory sensory neurons based on their odorant receptor expression, includes specialized microcircuits to create a tonically active inhibition and a separate feedback inhibition evoked by sensory input, and can be modulated by centrifugal projections.from other brain regions. Olfactory nerve output can also be modulated by dopaminergic circuitry, but this literature is more difficult to interpret. Presynaptic inhibition of olfactory afferents may extend their dynamic range but could also create state-dependent or odorant-specific sensory filters on primary sensory representations. New directions exploring this circuit's role in olfactory processing are discussed.
机译：突触前抑制是通过抑制输入到神经元突触前末端来抑制神经元释放神经递质。在嗅觉系统中，从嗅觉神经上皮到大脑嗅球的主要感觉传入受到突触前抑制作用的强烈调节，这种作用已在脑片和体内得到了广泛研究。在啮齿动物中，这种抑制作用是由球根中神经元释放的γ-氨基丁酸（GABA）和多巴胺介导的。众所周知，专门的GABA能回路包括表达GAD65的肾小球中间神经元的特定子集，其刺激突触前GABA_B受体以降低突触前钙电导。这种抑制的组织形式允许根据嗅觉感觉神经元特定群体的气味受体表达选择性调节神经递质的释放，包括专门的微电路以产生声调有效的抑制作用以及由感觉输入引起的单独的反馈抑制作用，并且可以通过来自其他大脑区域的离心投影。嗅觉神经输出也可通过多巴胺能回路进行调节，但该文献较难解释。嗅觉传入突触前抑制可能扩展其动态范围，但也可能在主要的感觉表征上产生状态相关或特定于气味的感觉过滤器。讨论了探索该电路在嗅觉处理中作用的新方向。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号