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Ontogeny of cytokine gene expression in the chicken spleen

机译：鸡脾细胞因子基因表达的个体发育

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摘要

Cytokine gene expression in the chicken spleen during embryogenesis and the early posthatch period was investigated in the present study. The constitutive expression of interleukin-4, interleukin-10, interleukin-18, and interferon-gamma genes was detectable as early as embryonic day 12. Expression of cytokine genes was higher in the spleen of posthatch chickens compared with chick embryos. There was a gradual increase in expression of all the cytokine genes in the spleen, which peaked by d 7 posthatch. This expression pattern coincided with the completion of T-cell colonization and structural development of the spleen during the early posthatch period. It is therefore possible that the cytokines examined in the present study are involved in the maturation of colonized T cells and in shaping the spleen microenvironment.
机译：在本研究中，研究了胚胎发生期间和孵化后早期鸡脾中细胞因子基因的表达。早在胚胎第12天就可检测到白细胞介素4，白细胞介素10，白细胞介素18和干扰素-γ基因的组成型表达。与雏鸡胚胎相比，孵化后鸡脾脏中细胞因子基因的表达更高。脾脏中所有细胞因子基因的表达逐渐增加，在孵化后第7天达到峰值。在孵化后早期，这种表达模式与T细胞定植的完成和脾的结构发育相吻合。因此，本研究中检查的细胞因子可能与定殖的T细胞的成熟以及脾脏微环境的形成有关。

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