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首页> 外文期刊>Chemical Senses >Effect of Ciguatoxin 3C on Voltage-Gated Na~+ and K~+ Currents in Mouse Taste Cells
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Effect of Ciguatoxin 3C on Voltage-Gated Na~+ and K~+ Currents in Mouse Taste Cells

机译：Ciguatoxin 3C对小鼠味觉细胞电压门控Na〜+和K〜+电流的影响

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摘要

The marine dinof lagellate Gambierdiscus toxicus produces highly lipophilic,polycyclic ether toxins that cause a seafood poisoning called ciguatera.Ciguatoxins (CTXs) and gambierol represent the two major causative agents of ciguatera intoxication,which include taste alterations (dysgeusiae).However,information on the mode of action of ciguatera toxins in taste cells is scarce.Here,we have studied the effect of synthetic CTX3C (a CTX congener) on mouse taste cells.By using the patch-clamp technique to monitor membrane ion currents,we found that CTX3C markedly affected the operation of voltage-gated Na~+ channels but was ineffective on voltage-gated K~+ channels.This result was the exact opposite of what we obtained earlier with gambierol,which inhibits K~+ channels but not Na~+ channels.Thus,CTXs and gambierol affect with high potency the operation of separate classes of voltage-gated ion channels in taste cells.Our data suggest that taste disturbances reported in ciguatera poisoning might be due to the ability of ciguatera toxins to interfere with ion channels in taste buds.
机译：海洋dinof胶质的Gambierdiscus toxicus产生高度亲脂性的多环醚毒素，导致海鲜中毒，称为Ciguatera。Ciguatoxins（CTXs）和gambierol代表了Ciguatera中毒的两种主要病因，包括味觉改变（dysgeusiae）。雪茄毒素在味觉细胞中的作用模式是稀缺的。在这里，我们研究了合成的CTX3C（一种CTX同源物）对小鼠味觉细胞的作用。​​通过使用膜片钳技术监测膜离子电流，我们发现CTX3C明显影响电压门控的Na〜+通道的操作，但对电压门控的K〜+通道无效。这一结果与我们先前用甘比罗尔获得的相反，后者抑制了K〜+通道，但不抑制Na〜+通道。因此，CTXs和甘比罗尔高效地影响味觉细胞中不同类别的电压门控离子通道的运行。我们的数据表明，在雪茄中毒中报道的味觉障碍可能是由于雪茄毒素干扰味蕾中离子通道的能力。

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