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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >MOLECULAR ANALYSIS OF A MOBILIZABLE THETA-MODE TRIMETHOPRIM RESISTANCE PLASMID FROM COAGULASE-NEGATIVE STAPHYLOCOCCI
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MOLECULAR ANALYSIS OF A MOBILIZABLE THETA-MODE TRIMETHOPRIM RESISTANCE PLASMID FROM COAGULASE-NEGATIVE STAPHYLOCOCCI

机译：凝固酶阴性金黄色葡萄球菌可动的θ型三乙嘧啶抗性质粒的分子分析

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摘要

The Staphylococcus epidermidis plasmid pSK639 is the prototype of a newly described family of small plasmids identified in clinical staphylococcal isolates. pSK639 is 8 kb in length and possesses a composite structure consisting of an IS257-flanked segment mediating trimethoprim resistance (Tp(r)), and regions responsible for replication and mobilization of the plasmid. Comparative sequence analysis suggests that a pSK639-like plasmid may represent a progenitor of previously identified staphylococcal Tp(r) determinants related to the transposon-like structure, Tn4003. In contrast to the small staphylococcal plasmids characterized to date that all utilize a rolling circle mode of replication, the replication region of pSK639 was found to contain features typical of an iteron-controlled theta-mode replicon. pSK639 is the first small plasmid of this type to be identified in the staphylococci. (C) 1997 Academic Press. [References: 44]
机译：表皮葡萄球菌质粒pSK639是在临床葡萄球菌分离物中鉴定的新描述的小质粒家族的原型。 pSK639的长度为8 kb，具有一个复合结构，由介导甲氧苄啶抗性（Tp（r））的IS257侧翼片段和负责质粒复制和动员的区域组成。比较序列分析表明，pSK639样质粒可能代表先前鉴定的与转座子样结构Tn4003有关的葡萄球菌Tp（r）决定簇的祖细胞。与迄今已表征为均使用滚环复制模式的小型葡萄球菌质粒相反，发现pSK639的复制区具有特异子控制的θ模式复制子的典型特征。 pSK639是第一个在葡萄球菌中鉴定的这种小质粒。 （C）1997学术出版社。 [参考：44]

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