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Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

机译：金属配位化学在探索和操纵细胞生物学中的应用

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Our desire to understand how the individual molecules that make up cells organize, interact, and communicate to form living systems has led to the burgeoning field of chemical biology, an interfacial area of science that combines aspects of chemistry (the study of matter and its transformations)and biology (the study of living things and their interactions with the environment). The defining feature of chemical biology is the use of chemical approaches and small molecules to interrogate or manipulate biology.1,2 These small molecules are synthetic or naturally occurring ones that, for example, bind to DNA to affect protein expression levels,bind to proteins to inhibit their function, interact with lipids to alter membrane integrity, or become fluorescent in response to a metabolic event. Because small molecules can affect biochemical function, there is a clear link between chemical biology and pharmacology and medicine.3 While small molecules are usually implied as being organic compounds,4 inorganic small molecules also have a long history in both biology and medicine. Ancient civilizations used gold and copper for healing purposes, and the modern era of drug discovery was ushered in when arsenic-containing salvarsan was discovered as an antisyphilis agent to become the world’s first blockbuster drug.5 Inorganic compounds should therefore not be overlooked in the realm of chemical biology, since their distinctive electronic, chemical, and photophysical properties render them particularly useful for a variety of applications.
机译：我们渴望了解组成细胞的各个分子如何组织，相互作用和沟通以形成生命系统的要求，导致了化学生物学领域的蓬勃发展，这是一个结合了化学方面（物质及其转化研究）的科学领域）和生物学（研究生物及其与环境的相互作用）。化学生物学的定义特征是使用化学方法和小分子来询问或操纵生物学。1,2这些小分子是合成的或天然存在的，例如与DNA结合以影响蛋白质表达水平，与蛋白质结合抑制其功能，与脂质相互作用以改变膜的完整性或响应代谢事件而发出荧光。由于小分子会影响生化功能，因此化学生物学与药理学和医学之间有着明确的联系。3虽然通常暗示小分子是有机化合物，但4在无机和生物学方面也有悠久的历史。古代文明使用黄金和铜来达到治疗目的，当发现含砷的Salvarsan作为抗梅毒剂成为世界上第一种重磅炸弹药物时，就迎来了药物发现的现代时代。5因此，无机化合物不应在领域中被忽视。因为它们具有独特的电子，化学和光物理性质，因此使其在各种应用中特别有用。

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