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首页> 外文期刊>Preparative biochemistry & biotechnology: An international journal for rapid communication >Study of Ibuprofen Glucopyranoside Derivative Synthesis by Candida antarctica Lipase in Organic Solvent
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Study of Ibuprofen Glucopyranoside Derivative Synthesis by Candida antarctica Lipase in Organic Solvent

机译：南极念珠菌脂肪酶在有机溶剂中合成布洛芬葡糖总糖苷衍生物的研究

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摘要

The direct esterification of ibuprofen and methyl a-D-glucopyranoside in organic solvent by Novozym 435 was investigated in terms of the main variables controlling the process,including initial water activity(a_w,0.05-0.75),incubation time,(0-168 h)and substrate concentration.The results showed that the lower initial a_w values resulted in higher enzymatic activity and bioconversion yield.The most appropriate initial a_w and incubation time were 0.06 and 144 h,respectively.The results also showed that the optimal ratio of ibuprofen to methyl alpha-D-glucopyranoside was 2.0.By optimizing these parameters,the yield increased about 50%.In addition,the product was confirmed to be methyl 6-O-(2'-(4'-isobutylphenyl)propionyl)D-alpha-glucopyranoside.
机译：研究了Novozym 435在有机溶剂中布洛芬和甲基aD-吡喃葡萄糖苷在有机溶剂中的直接酯化作用，主要控制过程包括初始水分活度（a_w，0.05-0.75），孵育时间，（0-168 h）和结果表明，较低的初始a_w值导致较高的酶活性和生物转化产量。最合适的初始a_w和孵育时间分别为0.06和144 h。结果还表明，布洛芬与甲基α的最佳比例-D-吡喃葡萄糖苷为2.0。通过优化这些参数，收率提高了约50％。此外，确认该产物为甲基6-O-（2'-（4'-异丁基苯基）丙酰基）D-α-吡喃葡萄糖苷。

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