Recent Trends in Nucleotide Synthesis

Roy Beatrice; Depaix Anais; Perigaud Christian; Peyrottes Suzanne

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Recent Trends in Nucleotide Synthesis

机译：核苷酸合成的最新趋势

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Focusing on the recent literature (since 2000), this review outlines the main synthetic approaches for the preparation of 5'-mono-, 5'-di-, and S'-triphosphorylated nucleosides, also known as nucleotides, as well as several derivatives, namely, cyclic nucleotides and dinucleotides, dinucleoside 5',5'-polyphosphates, sugar nucleotides, and nucleolipids. Endogenous nucleotides and their analogues can be obtained enzymatically, which is often restricted to natural substrates, or chemically. In chemical synthesis, protected or unprotected nucleosides can be used as the starting material, depending on the nature of the reagents selected from P(III) or P(V) species. Both solution-phase and solid-support syntheses have been developed and are reported here. Although a considerable amount of research has been conducted in this field, further work is required because chemists are still faced with the challenge of developing a universal methodology that is compatible with a large variety of nucleoside analogues.

机译：本综述着眼于最近的文献（自2000年起），概述了制备5'-单-，5'-di-和S'-三磷酸核苷（也称为核苷酸）以及几种衍生物的主要合成方法。，即环状核苷酸和二核苷酸，二核苷酸5'，5'-聚磷酸酯，糖核苷酸和核苷酸。内源核苷酸及其类似物可通过酶法获得，通常仅限于天然底物，或通过化学方法获得。在化学合成中，取决于选自P（III）或P（V）物种的试剂的性质，可以将受保护或未保护的核苷用作起始材料。溶液相和固相支持物的合成均已开发，并在此处进行了报道。尽管在该领域已经进行了大量研究，但是由于化学家仍面临开发与多种核苷类似物相容的通用方法的挑战，因此还需要进一步的工作。

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《Chemical Reviews》 |2016年第14期|共44页
作者
Roy Beatrice; Depaix Anais; Perigaud Christian; Peyrottes Suzanne;
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1. Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism [J] . Jun Yan, Ghows Azzam, Luke Freeman-Mills, Biology Open . 2014,第11期

机译：在神经发育和适应性代谢过程中，核苷酸的合成受细胞膜的形成调控。在神经发育和适应性代谢过程中，核苷酸的合成受细胞膜的形成调控。
2. Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition [J] . Adam Kraszewski, Joanna Romanowska, Agnieszka Szymańska-Michalak, BioTechnologia . 2014,第4期

机译：核苷酸类似物，核苷酸类似物的合成方法，核苷酸类似物的用途，抗病毒原核苷酸，药物组合物
3. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability [J] . Alexander J. Valvezan, Marc Turner, Amine Belaid, Cancer Cell . 2017,第5期

机译：MTORC1将核苷酸合成对核苷酸的需求致敬，导致有可命性的代谢脆弱性
4. SYNTHESIS OF NEW TYPES OF POTENTIALLY BIOACTIVE FURANOSYL NUCLEOSIDE AND NUCLEOTIDE ANALOGUES [C] . Andreia Fortuna, Nathalya Mesquita, Glaucius Oliva International Carbohydrate Symposium . 2018

机译：新型潜在生物活性呋喃糖基核苷和核苷酸类似物的合成
5. I:- Design, synthesis and study of nucleotide prodrugs. II:- Synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU) and study of its mechanism of action as a thymidine phosphorylase inhibitor. III:- Design and synthesis of novel nucleotide analogs as alternative substrates for studying the mechanism of the thymidylate synthase-catalyzed reaction. [D] . Jain, Harsh Vardhan. 2010

机译：I：-核苷酸前药的设计，合成和研究。 II：5-氟-6-[（（2-氨基咪唑-1-基）甲基]尿嘧啶（AIFU）的合成及其作为胸苷磷酸化酶抑制剂的作用机理的研究。 III：-设计和合成新型核苷酸类似物作为研究底物胸苷酸合酶催化反应机理的替代底物。
6. Nucleotides and Nucleotide Sugars in Developing Maize Endosperms (Synthesis of ADP-Glucose in brittle-1). [O] . J. C. Shannon, F. M. Pien, K. C. Liu 1996

机译：发育中的玉米胚乳中的核苷酸和核苷酸糖（脆性1中ADP-葡萄糖的合成）。
7. The oceans mediate the response of global climate to natural and anthropogenic forcings. Yet for the past 2,000 years — a key interval for understanding the present and future climate response to these forcings — global sea surface temperature changes and the underlying driving mechanisms are poorly constrained. Here we present a global synthesis of sea surface temperatures for the Common Era (ce) derived from 57 individual marine reconstructions that meet strict quality control criteria. We observe a cooling trend from 1 to 1800 ce that is robust against explicit tests for potential biases in the reconstructions. Between 801 and 1800 ce, the surface cooling trend is qualitatively consistent with an independent synthesis of terrestrial temperature reconstructions, and with a sea surface temperature composite derived from an ensemble of climate model simulations using best estimates of past external radiative forcings. Climate simulations using single and cumulative forcings suggest that the ocean surface cooling trend from 801 to 1800 ce is not primarily a response to orbital forcing but arises from a high frequency of explosive volcanism. Our results show that repeated clusters of volcanic eruptions can induce a net negative radiative forcing that results in a centennial and global scale cooling trend via a decline in mixed-layer oceanic heat content. [O] . McGregor, Helen V., Evans, Michael N., Goosse, Hugues, 2015

机译：海洋调节了全球气候对自然和人为强迫的响应。然而，在过去的2,000年中（这是了解当前和未来气候对这些强迫的响应的关键间隔），全球海表温度变化及其潜在的驱动机制受到的约束很有限。在这里，我们提出了一个共同的时期（ce）的全球海面温度的全球综合，该综合来自57个符合严格质量控制标准的海洋重建项目。我们观察到从1到1800 ce的冷却趋势，对于显式测试重建中潜在的偏倚而言，该趋势很稳健。在801至1800 ce之间，表面降温趋势在质量上与地面温度重建的独立合成以及从使用过去外部辐射强迫的最佳估计的气候模型模拟集合推导出的海面温度合成在质量上是一致的。使用单一和累积强迫的气候模拟表明，从801到1800 ce的海洋表面冷却趋势主要不是对轨道强迫的反应，而是爆炸性火山爆发的频繁发生。我们的结果表明，火山喷发的反复簇可引起净的负辐射强迫，这会导致混合层海洋热量降低而导致百年和全球规模的降温趋势。
8. Insertion of Nucleotides Opposite AP (Apurinic/Apyrimidinic) Sites in DNA During in Vitro Synthesis: The Uniqueness of Adenine Nucleotides [R] . Sagher, D., Strauss, B. 1983

机译：在体外合成期间在DNa中存在与ap（apurinic / apyrimidinic）位点相对的核苷酸的插入：腺嘌呤核苷酸的独特性

Recent Trends in Nucleotide Synthesis

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