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首页> 外文期刊>Biomaterials Science >Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery
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Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

机译：光交联的可生物降解的弹性体，可控制一氧化氮的输送

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摘要

The delivery of nitric oxide (NO) has important applications in medicine, especially for procedures that involve the vasculature. We report photo-curable biodegradable poly(diol citrate) elastomers capable of slow release of NO. A methacrylated poly(diol citrate) macromonomer was prepared by polycondensation of citric acid with 1,8-octanediol or 1,12-dodecanediol followed by functionalization with 2-aminoethyl methacrylate. A miscible NO donor, diazeniumdiolated N,N-diethyldiethylenetriamine, was synthesized and incorporated into the polymer matrix. An elastomeric network was obtained via photo-polymerization of macromonomers upon UV irradiation within three minutes. Films and tubes of the NO-releasing crosslinked macromonomers exhibited strong tensile strength and radial compressive strength, respectively. They also exhibited cell compatibility and biodegradability in vitro. Sustained NO release under physiological conditions was achieved for at least one week. NO release enhanced the proliferation of human umbilical vein endothelial cells but inhibited the proliferation of human aortic smooth muscle cells. Photo-polymerizable NO-releasing materials provide a new approach for the localized and sustained delivery of NO to treat thrombosis and restenosis in the vasculature.
机译：一氧化氮（NO）的输送在医学中具有重要的应用，特别是在涉及脉管系统的手术中。我们报告了能够缓慢释放NO的光固化生物可降解聚（柠檬酸二醇）弹性体。通过将柠檬酸与1,8-辛二醇或1,12-十二烷二醇缩聚，然后用甲基丙烯酸2-氨基乙酯官能化来制备甲基丙烯酸化的聚柠檬酸二醇大分子单体。合成了可混溶的NO供体，二氮烯化二氮烯化N，N-二乙基二亚乙基三胺，并掺入聚合物基质中。通过在三分钟内紫外线照射下大分子单体的光聚合获得弹性体网络。释放NO的交联大分子单体的膜和管分别表现出强的拉伸强度和径向压缩强度。它们还表现出细胞相容性和体外生物降解性。在生理条件下持续释放NO至少一周。 NO的释放增强了人脐静脉内皮细胞的增殖，但抑制了人主动脉平滑肌细胞的增殖。可光聚合的NO释放材料为NO的局部和持续输送提供了一种新方法，以治疗脉管系统中的血栓形成和再狭窄。

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