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Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer

机译：平均血小板体积可能是胃癌早期诊断和监测的生物标志物

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Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. The early diagnosis of gastric cancer is fundamental in decreasing the mortality rates. It has been shown that MPV level is a sign of inflammation in hepatocellular carcinoma and pancreatic adenocarcinoma. The aim of this study is to examine whether MPV would be a useful inflammatory marker for differentiating gastric cancer patients from healthy controls. Thirty-one gastric cancer patients and 31 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects (8.31 fL vs. 7.85; p: 0.007). ROC analysis suggested 8.25 fL as the cut-off value for MPV (AUC: 0.717, sensitivity: 61%, specificity: 81%). Surgical tumor resection resulted in a significant decrease in MPV level (8.31 fL vs. 7.55 fL; p: 0.001). No significant difference was found in MPV level between the post-operative group and control subjects. We did not find statistically significant difference between MPV and TNM stages. In conclusion, changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients for GC risk and may prompt physicians to make an early diagnosis of GC.
机译：胃癌是全球第四大常见癌症，也是癌症相关死亡的第二大原因。胃癌的早期诊断对于降低死亡率至关重要。已经表明，MPV水平是肝细胞癌和胰腺腺癌中炎症的标志。这项研究的目的是检查MPV是否会成为区分胃癌患者和健康对照者的有用炎症标记。该研究纳入了31名胃癌患者和31名年龄相匹配的健康受试者。该研究排除了患有高血压，血液和肾脏疾病，心力衰竭，慢性感染，肝病和其他癌症的患者。与健康受试者相比，术前胃癌患者的MPV水平显着更高（8.31 fL vs. 7.85; p：0.007）。 ROC分析建议MPV的临界值为8.25 fL（AUC：0.717，灵敏度：61％，特异性：81％）。手术切除肿瘤导致MPV水平显着下降（8.31 fL对7.55 fL; p：0.001）。术后组与对照组受试者的MPV水平无明显差异。我们没有发现MPV和TNM阶段之间的统计学差异。总之，MPV值的变化可用作监测健康患者发生GC风险的容易获得的生物标记，并可能促使医生对GC进行早期诊断。

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