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首页> 外文期刊>Platelets >Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease.
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Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease.

机译：冠心病患者血小板活化与内皮功能障碍之间的功能相互作用。

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Platelet-monocyte binding and surface P-selectin expression are sensitive markers of platelet activation. Endothelium-derived factors are known to inhibit platelet activation and may confer important anti-atherothrombotic effects. We assessed the relationship between platelet activation and endothelium-dependent vasomotion in patients with coronary heart disease (CHD). Twenty male patients with stable CHD were compared with 20 healthy men. Platelet-monocyte binding and platelet surface expression of P-selectin were assessed using two-colour flow cytometry on whole blood. Forearm blood flow was assessed in patients using venous occlusion plethysmography during intra-arterial infusions of substance P, acetylcholine and sodium nitroprusside. Platelet activation was higher in patients than healthy men (platelet-monocyte binding, 27 +/- 3 vs. 20 +/- 1%; P < 0.05). In patients with CHD, there was an inverse correlation between maximal substance P induced vasodilatation and both platelet-monocyte binding (P =0.003) and P-selectin expression (P = 0.02). A similar correlation was observed between platelet-monocyte binding and the vasomotor response to acetylcholine (P = 0.08) but not with sodium nitroprusside. In patients with stable coronary heart disease, there is a strong inverse relationship between markers of platelet activation and endothelium-dependent vasomotor function. This may explain the pathophysiological mechanism linking endothelial vasomotor dysfunction and the risk of acute atherothrombotic events.
机译：血小板-单核细胞结合和表面P-选择素表达是血小板活化的敏感标志物。已知内皮来源的因子抑制血小板活化，并可能赋予重要的抗动脉血栓形成作用。我们评估了冠心病（CHD）患者的血小板活化与内皮依赖性血管舒张之间的关系。将20名CHD稳定的男性患者与20名健康男性进行比较。 P-选择素的血小板-单核细胞结合和血小板表面表达是通过全血双色流式细胞术评估的。在动脉内输注P物质，乙酰胆碱和硝普钠的过程中，使用静脉阻塞体积描记法评估了患者的前臂血流量。患者的血小板活化高于健康男性（血小板-单核细胞结合，27 +/- 3比20 +/- 1％; P <0.05）。在冠心病患者中，最大的物质P诱导的血管舒张与血小板-单核细胞结合（P = 0.003）和P-选择素表达（P = 0.02）之间呈负相关。在血小板-单核细胞结合和对乙酰胆碱的血管舒缩反应之间观察到相似的相关性（P = 0.08），但硝普钠没有。在患有稳定型冠心病的患者中，血小板活化标志物与内皮依赖性血管舒缩功能之间存在很强的逆向关系。这可能解释了将内皮血管舒缩功能障碍与急性动脉粥样硬化血栓形成事件的风险联系起来的病理生理机制。

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