Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin-Antitoxin Modules

Remy Loris; Abel Garcia-Pino

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Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin-Antitoxin Modules

机译：毒素-抗毒素模块中基于疾病和动力学的调节机制

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Intrinsic disorder in proteins has been studied in a large number of contexts in eukaryotes but has received less attention in prokaryotes. In this review, we show by using bacterial toxin?antitoxin modules as a paradigm that, while less prevalent than in eukaryotes, intrinsic disorder in proteins from prokaryotes can be functionally important and that this functionality is not restricted to simple folding upon binding transitions.

机译：在真核生物中已经对蛋白质的内在障碍进行了大量研究，但在原核生物中却很少受到关注。在这篇综述中，我们通过使用细菌毒素-抗毒素模块作为范例来说明，虽然不如真核生物那么普遍，但原核生物蛋白质中的内在障碍可能在功能上很重要，并且这种功能不限于结合转换后的简单折叠。

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《Chemical Reviews》 |2014年第13期|共15页
作者
Remy Loris; Abel Garcia-Pino;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Disorder- and Dynamics-Based; Regulatory Mechanisms; Toxin-Antitoxin;

机译：基于疾病和动力学的调节机制;抗毒素;

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专利

1. Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin-Antitoxin Modules [J] . Remy Loris, Abel Garcia-Pino Chemical Reviews . 2014,第13期

机译：毒素-抗毒素模块中基于疾病和动力学的调节机制
2. Co-expression module analysis reveals biological processes, genomic gain, and regulatory mechanisms associated with breast cancer progression [J] . Zhiao Shi, Catherine K Derow, Bing Zhang BMC Systems Biology . 2010,第1期

机译：共表达模块分析揭示了与乳腺癌进展相关的生物学过程，基因组增益和调控机制
3. Elucidation of the mechanism of the regulatory function of the Ig1 module of the fibroblast growth factor receptor 1. [J] . Kiselyov VV, Kochoyan A, Poulsen FM, Protein Science: A Publication of the Protein Society . 2006,第10期

机译：阐明成纤维细胞生长因子受体1的Ig1模块调节功能的机制。
4. TOXIN-ANTITOXIN MODULES AND SYMBIOSIS [C] . M. Bodogai, Sz. Ferenczi, S. P. Miclea, International Conference of the African Association for Biological Nitrogen Fixation . 2008

机译：毒素 - 抗毒素模块和共生
5. Regulatory Networks in Development: Understanding the role of cis-regulatory modules in Gene Regulatory Network evolution. [D] . Suryamohan, Kushal. 2016

机译：发展中的调控网络：了解顺式调控模块在基因调控网络进化中的作用。
6. Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site [O] . Guang-Yao Li, Yonglong Zhang, Masayori Inouye, 2009

机译：大肠杆菌RelE-RelB的抑制机制毒素-抗毒素模块涉及mRNA干扰酶附近的螺旋位移。活性现场
7. Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site*S⃞ [O] . Li, Guang-Yao, Zhang, Yonglong, Inouye, Masayori, 2009

机译：大肠杆菌RelE-RelB的抑制机制毒素-抗毒素模块涉及mRNA干扰酶附近的螺旋位移。活性网站*S⃞

Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin-Antitoxin Modules

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