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首页> 外文期刊>Prescrire international >Risk of preterm delivery: A single course of antenatal corticosteroids
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Risk of preterm delivery: A single course of antenatal corticosteroids

机译：早产的风险：产前皮质类固醇单疗程

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? For women at risk of delivery before 34 weeks of gestation, administration of betamethasone or dexamethasone for 24 or 36 hours reduces neonatal morbidity and mortality. ? In a double-blind randomised trial involving 1858 pregnant women, who received either a single course of corticosteroids or multiple courses every 14 days, no statistically significant difference in the rates of mortality and respiratory morbidity were observed during the 28 first days of life. Newborns had decreased height, weight and head circumference in the group treated every 14 days. ? No difference in outcome was noted at 2 years among 1047 infants whose mothers had received a single course of betamethasone or weekly treatment up to 32 weeks of gestation. ? Similarly, no difference in outcome was observed among 556 children whose mothers had received an initial course of betamethasone followed by regular injections of either betamethasone or placebo. However, 6 children (2.9%) exposed to repeated maternal treatment developed cerebral palsy, versus only one of the children (0.5%) exposed to a single course, indicating that repeat courses of antenatal corticosteroids might have a detrimental effect. ? In practice, it seems prudent to only use a single course of corticosteroids in this setting.
机译：？对于妊娠34周之前有分娩危险的妇女，给予倍他米松或地塞米松24或36小时可降低新生儿的发病率和死亡率。 ？在一项涉及1858名孕妇的双盲随机试验中，这些孕妇每14天接受一次皮质类固醇激素治疗或多疗程，在出生后28天内，死亡率和呼吸系统发病率均无统计学意义的显着差异。每14天治疗组新生儿的身高，体重和头围下降。 ？在1047例婴儿中，其母亲接受了单次倍他米松疗程或每周妊娠至32周的治疗，其2岁时的结局无差异。 ？同样，在556名母亲接受初次使用倍他米松，随后定期注射倍他米松或安慰剂的儿童中，未观察到结局差异。但是，有6名儿童（2.9％）接受了反复的孕产妇治疗后发展为脑瘫，而只有1名儿童（0.5％）接受了单一疗程，表明重复疗程的产前皮质类固醇激素可能具有有害作用。 ？在实践中，在这种情况下仅使用单一疗程的皮质类固醇似乎是明智的。

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