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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer.
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Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer.

机译：主动吸烟，家庭被动吸烟以及发生胰腺癌的风险。

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OBJECTIVE: The objective of this study was to examine the association between active cigarette smoking, household passive smoke exposure, and pancreatic cancer risk using a prospective cohort design. METHODS: Two cohorts were established in Washington County, Maryland in 1963 (n = 45,749) and 1975 (n = 48,172). The Washington County Cancer Registry was used to ascertain the occurrence of pancreatic cancer in the 1963 cohort from 1963-1978 and in the 1975 cohort from 1975-1994. Poisson regression was used to analyze the associations between active smoking and household passive smoke exposure and pancreatic cancer risk. RESULTS: Current active smoking was associated with a two-fold increased risk of pancreatic cancer in both cohorts. Among never-smokers in each cohort, exposure to household passive smoke was not associated with an increased risk of pancreatic cancer, although the confidence limits were wide due to a small number of cases. CONCLUSIONS: This study further documents the approximate doublingof pancreatic cancer risk in current active smokers. Our results also indicate that household passive smoke exposure is not associated with pancreatic cancer risk, although our risk estimates lacked precision.
机译：目的：本研究的目的是使用前瞻性队列设计研究主动吸烟，家庭被动吸烟和胰腺癌风险之间的关系。方法：分别于1963年（n = 45749）和1975年（n = 48172）在马里兰州华盛顿县建立了两个队列。在1963-1978年的1963年队列和1975-1994年的1975年队列中，华盛顿县癌症登记处用于确定胰腺癌的发生。 Poisson回归用于分析主动吸烟和家庭被动吸烟与胰腺癌风险之间的关系。结果：当前的积极吸烟与两个人群的胰腺癌风险增加了两倍有关。在每个队列中从不吸烟者中，尽管由于少数病例而置信范围很广，但暴露于家庭被动吸烟与胰腺癌风险增加无关。结论：本研究进一步证明了当前活跃吸烟者胰腺癌风险大约翻倍。我们的结果还表明，尽管我们的风险估计缺乏准确性，但家庭被动吸烟与胰腺癌的风险无关。

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