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Artificial sweetener consumption and urinary tract tumors in Cordoba, Argentina.

机译:阿根廷科尔多瓦的人造甜味剂消耗量和尿路肿瘤。

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OBJECTIVE: To determine the role of the habitual use of the most common artificial sweeteners (AS) in the development of urinary tract tumors (UTT) in Argentina. METHODS: Case-control study of 197 patients with histologically confirmed UTT of transitional varieties, and 397 controls with acute, non-neoplastic, and non-urinary tract diseases, admitted to the same hospitals in Cordoba (Argentina) between 1999 and 2006. All subjects were interviewed about their use of AS and their exposure to other known or suspected risk factors for UTT. RESULTS: Fifty-one UTT patients (26%) and 87 controls (22%) used AS. The risk of UTT was significantly increased in long-term ( or =10 years) AS users compared with none-AS users. The OR (95% CI) for long-term consumers was 2.18 (1.22-3.89) and for short-term users was 1.10 (0.61-2.00) after adjustment for age, gender, BMI, social status. and years of tobacco use. CONCLUSION: Regular use of AS for 10 years or more was positively associated with UTT.
机译:目的:确定习惯使用最常见的人造甜味剂(AS)在阿根廷发生尿路肿瘤(UTT)中的作用。方法:1999年至2006年之间,在科尔多瓦(阿根廷)的同一家医院中对197例经组织学证实为过渡性变种的UTT的患者和397例患有急性,非肿瘤性和非尿路疾病的对照进行了病例对照研究。对受试者进行了关于他们使用AS以及暴露于其他已知或怀疑的UTT危险因素的采访。结果:51例UTT患者(26%)和87例对照(22%)使用了AS。与不使用AS的用户相比,长期(>或= 10年)AS用户的UTT风险显着增加。调整年龄,性别,BMI和社会地位后,长期消费者的OR(95%CI)为2.18(1.22-3.89),短期消费者为1.10(0.61-2.00)。和多年的烟草使用。结论:定期使用AS 10年或更长时间与UTT呈正相关。

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