Methylphenidate: growth retardation.

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Methylphenidate: growth retardation.

机译：哌醋甲酯：生长迟缓。

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Methylphenidate is an amphetamine psychostimulant used as a symptomatic treatment for attention-deficit hyperactivity disorder. A randomised trial examined changes in the height and weight of 521 hyperactive children. After 14 months, children treated with methylphenidate had gained less height and less weight (-1.23 cm per year and -2.48 kg per year) than untreated children. After 3 years, the differences were about 2 cm and 2.7 kg. Systematic reviews have provided similar results: methylphenidate slows growth by about 1 to 1.5 cm per year. Catch-up growth usually occurs during a 2-year period after methylphenidate withdrawal. Studies of final adult height have shown no statistically significant difference versus never-treated individuals. The effect of methylphenidate on growth is probably due to its impact in reducing appetite. Dexamfetamine is sometimes used as an alternative to methylphenidate and has similar effects on growth, as is the case with atomoxetine. In practice, prescription renewal provides a good opportunity to measure these children's growth. Marked growth retardation may warrant treatment interruption or a dose reduction.

机译：哌醋甲酯是一种苯丙胺类精神刺激药，用于治疗注意力不足过动症。一项随机试验检查了521名多动症儿童的身高和体重的变化。 14个月后，用哌醋甲酯治疗的儿童身高和体重（每年-1.23厘米，每年-2.48千克）比未治疗的儿童低。 3年后，差异约为2厘米和2.7公斤。系统评价提供了类似的结果：哌醋甲酯每年使生长减慢约1到1.5厘米。追赶生长通常发生在哌醋甲酯停药后的2年内。最终成人身高的研究表明，与从未治疗的个体相比，没有统计学上的显着差异。哌醋甲酯对生长的影响可能是由于其降低食欲的影响。地塞米特有时被用作哌醋甲酯的替代品，并且与阿托西汀一样对生长具有相似的作用。在实践中，处方更新为衡量这些孩子的成长提供了一个很好的机会。明显的生长迟缓可能需要中断治疗或降低剂量。

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《Prescrire international》 |2011年第120期|共2页
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Anonymous;
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Methylphenidate: growth retardation.

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