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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >The Alberta Physical Activity and Breast Cancer Prevention Trial: quality of life outcomes.
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The Alberta Physical Activity and Breast Cancer Prevention Trial: quality of life outcomes.

机译：艾伯塔省体育锻炼和乳腺癌预防试验：生活质量。

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OBJECTIVE: Interventions for disease prevention should also be evaluated for quality of life (QoL) effects. Few exercise trials have examined QoL in the context of primary disease prevention. Here, we report the QoL outcomes from the Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial. METHODS: The ALPHA trial was a randomized controlled trial in Calgary and Edmonton, Canada between May 2003 and July 2007 that compared an exercise intervention to a sedentary lifestyle among 320 sedentary, postmenopausal women. The exercise group was asked to perform moderate-to-vigorous intensity aerobic exercise 45 min/day, 5 days/week for 1 year. QoL was assessed by the short form-36 health survey. RESULTS: Compared to the control group, the exercise group maintained significantly better physical functioning (p<0.001), general health (p<0.001), vitality (p=0.002), and bodily pain (p=0.020) by 4-5 points which exceeds the 3.0 minimally important difference for these scales. Changes in body composition partially mediated the intervention effects. Antidepressant use and the presence of comorbidities moderated some intervention effects. CONCLUSIONS: A 1-year moderate-to-vigorous aerobic exercise program prevents declines in the physical aspects of QoL in postmenopausal women. Exercise may have a potentially important advantage for breast cancer prevention compared to other lifestyle or biomedical interventions.
机译：目的：还应评估疾病预防干预措施的生活质量（QoL）影响。很少有运动试验在预防原发疾病的背景下检查生活质量。在这里，我们报告了艾伯塔省体育锻炼和乳腺癌预防（ALPHA）试验的QoL结果。方法：ALPHA试验是2003年5月至2007年7月在加拿大卡尔加里和埃德蒙顿进行的一项随机对照试验，比较了320名绝经后久坐的绝经后妇女的运动干预与久坐的生活方式。运动组被要求进行45分钟/天，5天/周的中度到剧烈强度的有氧运动，持续1年。通过简短的36型健康调查评估了生活质量。结果：与对照组相比，运动组的身体机能（p <0.001），总体健康（p <0.001），活力（p = 0.002）和身体疼痛（p = 0.020）显着改善了4-5点。对于这些量表，它超过了3.0的最小重要差异。身体成分的变化部分介导了干预作用。抗抑郁药的使用和合并症的出现减轻了一些干预作用。结论：一项为期1年的中度至剧烈有氧运动计划可防止绝经后妇女的QoL身体状况下降。与其他生活方式或生物医学干预相比，锻炼对预防乳腺癌可能具有潜在的重要优势。

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