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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Meta-analysis: Serum vitamin D and colorectal adenoma risk.
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Meta-analysis: Serum vitamin D and colorectal adenoma risk.

机译：荟萃分析：血清维生素D和大肠腺瘤风险。

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摘要

OBJECTIVE: To perform a systematic review and meta-analysis of human studies on the association between serum 25 hydroxyvitamin D (25(OH)D) and incident, sporadic colorectal adenoma (CRA) and CRA recurrence. METHODS: Relevant studies among humans were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. Due to the heterogeneity across studies in categorizing serum vitamin D levels, all results were recalculated for an increase of serum 25(OH)D by 20 ng/ml. Summary odds ratios (ORs) were calculated using meta-analysis methods. RESULTS: Overall, 10 original studies were included. Specific results for incident CRA according to serum 25(OH)D were reported in 8 studies, and for CRA recurrence in 2 studies, respectively. In meta-analyses, summary ORs (95% confidence intervals) regarding incident and recurrent CRA, and both outcomes combined were 0.82 (0.69-0.97), 0.87 (0.56-1.35), and 0.84 (0.72-0.97), respectively, for an increase of 25(OH)D by 20 ng/ml. No publication bias was found. CONCLUSION: Our results support suggestions that serum 25(OH)D levels are inversely associated with CRA risk.
机译：目的：对人体研究中血清25羟维生素D（25（OH）D）与偶发性散发性结直肠腺瘤（CRA）和CRA复发之间的关系进行系统的回顾和荟萃分析。方法：通过系统地搜索Ovid Medline，EMBASE和ISI Web of Knowledge数据库并通过交叉引用，可以确定人类之间的相关研究。由于对血清维生素D水平进行分类的研究存在异质性，因此重新计算了所有结果，以使血清25（OH）D增加20 ng / ml。使用荟萃分析方法计算汇总比值比（OR）。结果：总体上，包括10项原始研究。分别在8项研究中报告了根据血清25（OH）D发生CRA的具体结果，在2项研究中报告了CRA复发的具体结果。在荟萃分析中，关于事件和复发性CRA的摘要OR（95％置信区间）以及两个结局的总和分别为0.82（0.69-0.97），0.87（0.56-1.35）和0.84（0.72-0.97）。 25（OH）D增加20 ng / ml。找不到发布偏见。结论：我们的研究结果提示血清25（OH）D水平与CRA风险呈负相关。

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