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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Genital HPV infection and related lesions in men.
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Genital HPV infection and related lesions in men.

机译：男性生殖器HPV感染及相关病变。

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摘要

Human papillomavirus (HPV) is highly prevalent in men and there is an interest in further understanding the relationship between HPV infection and disease in men, including the development of genital warts, penile intraepithelial neoplasia and invasive penile carcinomas. Genital warts are caused by HPV 6/11 and are the most common clinical manifestation of HPV in men. Though they are benign and not associated with mortality, they are a source of psychosocial distress and physical discomfort. HPV infection can also develop into invasive penile carcinoma which is associated with morbidity and mortality. Approximately 40% of invasive penile carcinomas are attributable to HPV with HPV 16, 18, and 6/11 being the genotypes most commonly detected in penile tumors. Penile carcinomas of the basaloid and warty histologic subtypes are most likely to test positive for HPV. In addition to HPV infection, the risk factors most strongly associated with penile cancer are lack of neonatal circumcision, phimosis (the inability of uncircumcised men to fully retract the foreskin), and anogenital warts. Male vaccination with the quadrivalent HPV vaccine that protects against HPV 6/11/16/18 has been shown to significantly reduce HPV-associated anogenital infection and disease in men. If the quadrivalent vaccine is successfully disseminated to large segments of the young male population, there is the potential for substantial reduction in genital HPV infection and related lesions in men.
机译：人乳头瘤病毒（HPV）在男性中非常普遍，因此有兴趣进一步了解HPV感染与男性疾病之间的关系，包括生殖器疣，阴茎上皮内瘤变和浸润性阴茎癌的发展。尖锐湿疣是由HPV 6/11引起的，是男性中HPV的最常见临床表现。尽管它们是良性的，并且与死亡率无关，但它们是社会心理困扰和身体不适的根源。 HPV感染还可发展成浸润性阴茎癌，与发病率和死亡率有关。大约40％的浸润性阴茎癌可归因于HPV，其中HPV 16、18和6/11是在阴茎肿瘤中最常见的基因型。基底型和疣型组织学亚型的阴茎癌最有可能检测HPV阳性。除HPV感染外，与阴茎癌最密切相关的危险因素是新生儿包皮环切术，包茎（未割包皮的男性无法完全缩回包皮）和肛门生殖器疣。已证明，使用预防HPV 6/11/16/18的四价HPV疫苗对男性进行疫苗接种可显着减少男性与HPV相关的肛门生殖器感染和疾病。如果四价疫苗成功地传播到了大部分的年轻男性人群中，则可能大大减少男性生殖器HPV感染和相关病变。

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