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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Lead time and down-staging in the survival of cervical cancer cases detected by screening
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Lead time and down-staging in the survival of cervical cancer cases detected by screening

机译：通过筛查发现宫颈癌病例的提前期和分期

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摘要

We have read with interest the article by Zucchetto and colleagues about the survival of patients with invasive cervical cancer according to their participation in organized cervical screening (Zucchetto et al., 2013). To compare the survival of patients by whether their cancer had been detected within or outside of the organized screening program, the authors computed a logrank test and hazard ratios adjusted for age at diagnosis, area of residence, country of birth and histological type. These results are very difficult to interpret because of the lead time introduced by screening, and are overestimates of the benefit of screening on survival. To attenuate the problem, the authors further adjusted the hazard ratios for stage at cancer diagnosis. However, the problem of the lead time bias introduced by screening requires even more attention.
机译：我们感兴趣地阅读了Zucchetto及其同事关于浸润性宫颈癌患者根据其参与有组织的宫颈癌筛查的存活情况的文章（Zucchetto等，2013）。为了通过在有组织的筛查程序之内或之外检测到患者的癌症来比较患者的生存率，作者计算了对数秩和检验和风险比，并根据诊断时的年龄，居住地区，出生国家和组织学类型对风险比进行了调整。由于筛选带来的交货时间，这些结果很难解释，并且高估了筛选对生存的益处。为了减轻这个问题，作者进一步调整了癌症诊断阶段的危险比。但是，筛选带来的提前期偏差问题需要引起更多关注。

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