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A risk table to assist health practitioners assess and prevent the onset of depression in later life

机译:风险表,可帮助医疗从业人员评估和预防以后的抑郁症发作

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Objective: This study aimed to develop a simple risk table of modifiable factors prospectively associated with depression in later life that could be used to guide the assessment, management and introduction of preventive strategies in clinical practice. Methods: This retrospective cohort study included 4636 men aged 65 to 83years living in the community who denied history of past diagnosis or treatment for depression. They self-reported information about their physical activity, weight and height, smoking history, alcohol consumption and dietary habits, as well as history of hypertension, diabetes, coronary heart disease and stroke. We calculated the body mass index (BMI) in kg/m2. Three to 8years later they were assessed with the Geriatric Depression Scale 15 (GDS-15) and those with a total score of 7 or greater were considered to display clinically significant symptoms of depression. We used binomial exponentiated log-linked general linear models to estimate the risk ratio (RR) and 95% confidence interval (95% CI) of incident depression after adjusting for age, education, marital status and prevalent medical illnesses. We calculated the probability of depression for each individual combination of risk factors and displayed the results in a risk table. Results: Two hundred and twenty-nine men (4.5%) showed evidence of incident depression 5.7. ±. 0.9 (mean. ±. standard deviation) years later. Measured dietary factors showed no association with incident depression. The probability of depression was the highest for older men who were underweight, overweight or obese, physically inactive, risk drinkers and smokers (12.0%, 95% CI = 7.0%, 17.1%), and the lowest for those who had all 4 healthy lifestyle markers: physically active, normal body mass, non-risk drinking and non-smoking (1.6%, 95% CI = 0.6%, 2.5%). The probability of incident depression fell between these two extremes for different combinations of lifestyle practices. Conclusion: Four modifiable lifestyle factors can be used in combination to produce a risk table that predicts the probability of incident depression over a period of 3 to 8. years. The risk table is simple, informative and can be easily incorporated into clinical practice to guide assessment and risk reduction interventions.
机译:目的:本研究旨在建立一个简单的可改变因素风险表,该可变表因素可能与以后的抑郁症有关,可用于指导临床实践中预防策略的评估,管理和引入。方法:这项回顾性队列研究纳入了4636名年龄在65至83岁之间的社区居民,他们否认曾有过抑郁症的诊断或治疗史。他们自我报告有关其身体活动,体重和身高,吸烟史,饮酒和饮食习惯以及高血压,糖尿病,冠心病和中风病史的信息。我们以kg / m2为单位计算了体重指数(BMI)。三到八年后,他们用老年抑郁量表15(GDS-15)进行了评估,总分7或更高的那些被认为具有临床上显着的抑郁症状。在调整了年龄,教育程度,婚姻状况和普遍的医疗疾病之后,我们使用了二项式指数对数关联的一般线性模型来估计抑郁症的风险比(RR)和95%置信区间(95%CI)。我们针对每种风险因素组合计算出抑郁的可能性,并将结果显示在风险表中。结果:229名男性(4.5%)表现出抑郁症的证据5.7。 ±。 0.9年(平均±标准偏差)。饮食因素显示与抑郁症无关。体重不足,超重或肥胖,缺乏运动,有饮酒危险和吸烟的老年男性患抑郁症的可能性最高(12.0%,95%CI = 7.0%,17.1%),而所有四个健康人群的抑郁可能性最低生活方式标志:体育锻炼,正常体重,无危险饮酒和禁烟(1.6%,95%CI = 0.6%,2.5%)。对于生活方式的不同组合,发生抑郁事件的可能性介于这两个极端之间。结论:可以将四种可改变的生活方式因素结合使用,以生成风险表,该表预测3至8年内发生抑郁症的可能性。风险表简单,信息量大,可以轻松地纳入临床实践中,以指导评估和降低风险干预措施。

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