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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >No interaction of body mass index and smoking on diabetes mellitus risk in elderly women.
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No interaction of body mass index and smoking on diabetes mellitus risk in elderly women.

机译：体重指数和吸烟对老年妇女的糖尿病风险没有影响。

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摘要

OBJECTIVE: We sought to assess the interaction of smoking and body mass index (BMI) on diabetes risk. METHODS: We analyzed data from a community-based prospective cohort of 41,836 women from Iowa who completed a baseline survey in 1986 and five subsequent surveys through 2004. The final analysis included 36,839 participants. RESULTS: At baseline (1986), there were 66% never smokers, 20% former smokers, and 14% current smokers. Subjects represented 40% normal weight, 38% overweight, and 22% obese individuals. Compared to normal weight women, the hazard ratio (HR) for diabetes was increased in overweight (HR 1.96; 95% CI 1.75-2.19) and obese subjects (HR 3.58; 95% CI 3.19-4.02). The hazard ratio for diabetes increased in a dose-dependent manner with smoking intensity. Compared to never smokers, former smokers had a higher risk for diabetes (HR 1.22; 95% CI 1.11-1.34). Among current smokers, the hazard ratio for diabetes was 1.21 (95% CI 0.95-1.53) for 1-19 pack-year smokers, 1.33 (95% CI 1.12-1.57) for 20-39 pack-year smokers, and 1.45 (95% CI 1.23-1.71) for > or =40 pack-year smokers. Similar trends were observed when the results were stratified by BMI. A test of interaction between BMI and smoking on diabetes risk was not statistically significant. CONCLUSIONS: Our findings suggest that smoking increases diabetes risk through a BMI-independent mechanism.
机译：目的：我们试图评估吸烟与体重指数（BMI）在糖尿病风险中的相互作用。方法：我们分析了来自爱荷华州的41,836名妇女的社区前瞻性队列数据，他们在1986年完成了基线调查，并在2004年之前完成了五项后续调查。最终分析包括36,839名参与者。结果：在基线（1986年）时，从未吸烟者占66％，曾经吸烟者占20％，目前吸烟者占14％。受试者代表40％正常体重，38％超重和22％肥胖个体。与体重正常的女性相比，超重（HR 1.96; 95％CI 1.75-2.19）和肥胖受试者（HR 3.58; 95％CI 3.19-4.02）增加了糖尿病的危险比（HR）。糖尿病的危险比随吸烟强度呈剂量依赖性增加。与从不吸烟者相比，前吸烟者患糖尿病的风险更高（HR 1.22; 95％CI 1.11-1.34）。在目前的吸烟者中，1-19岁年吸烟者的糖尿病风险比为1.21（95％CI 0.95-1.53​​），20-39岁年龄吸烟者为1.33（95％CI 1.12-1.57）和1.45（95 ％CI 1.23-1.71），对于>或= 40包年吸烟者。通过BMI对结果进行分层时，观察到相似的趋势。 BMI和吸烟之间对糖尿病风险的相互作用测试没有统计学意义。结论：我们的研究结果表明吸烟是通过不依赖BMI的机制增加患糖尿病的风险。

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