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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese.
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Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese.

机译：在日本中年人中，较高的饮食摄入α-亚麻酸与较低的胰岛素抵抗相关。

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摘要

OBJECTIVE: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. METHOD: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis. RESULTS: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25 kg/m(2) (P for interaction=0.033). However EPA+DHA showed no such associations consistently. CONCLUSION: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.
机译：目的：研究瘦人群中n-3多不饱和脂肪酸（植物来源的α-亚麻酸：ALA，海洋来源的二十碳五烯酸和二十二碳六烯酸：EPA + DHA）的饮食摄入与胰岛素抵抗（IR）之间的关系高n-3 PUFA摄入量。方法：我们在2002年横断面研究了3383名年龄在35-66岁之间的日本地方政府工作人员。IR被定义为体内稳态模型评估的最高四分位数，营养摄入量是根据饮食史调查表估算的。通过逻辑回归分析计算以ALA或EPA + DHA摄入量最低的四分位数作为参考的IR的优势比（OR）。结果：平均年龄，体重指数（BMI）和饮食ALA以及饮食中EPA + DHA的中位数分别为47.9岁，22.9 kg / m（2）和1.90 g /天（0.88％E）和0.77 g /天（分别为0.36％E）。在ALA摄入量的四分位数中，IR的OR降低（Q4与Q1的多元校正OR = 0.74，P = 0.01），仅在BMI <25 kg / m（2）的受试者中观察到相关性（互动的P = 0.033）。但是，EPA + DHA并没有始终显示出这种关联。结论：日本中年男女体重正常的人中，ALA摄入量较高与IR患病率降低显着相关。

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