OBJECTIVE: Genetic factors account for 40%-70% of the variation in body mass index (BMI). We sought to test whether moderate intensity physical activity affected parent-offspring relationships for body mass index and regional adiposity in 26,587 female and 6428 male walkers surveyed in the United States in 2000. METHODS: Survey questionnaires provided self-reported usual walking distance, height, weight, and waist circumference, and mother's and father's adiposity (1=lean, 2=normal, 3=overweight, and 4=very overweight). Regression analyses were used to test whether the contribution of parental adiposities to the walkers' body mass indexes and waist circumferences diminished with walking. RESULTS: In the most sedentary group (walking < 1.5 km/d), average parental adiposity was a significant determinant of the walkers' body mass indexes and waist circumferences (female: P < 10(-15); male: P < 10(-13)). Greater walking distance significantly diminished the effect of average parents' adiposity on the walkers' body mass indexes (female: P < 10(-10); male P = 0.003) and waist circumferences (female: P < 10(-6); male P = 0.01). Compared to the most sedentary female walkers, the effect of parental adiposity was reduced 36% for body mass indexes and 41% for waist circumferences (corresponding reductions in men were 36% and 46%, respectively). CONCLUSION: These results suggest that moderate intensity physical activity attenuates inheritance of both total and regional adiposity in a dose-dependent manner.
展开▼
机译：目的：遗传因素占体重指数（BMI）变异的40％-70％。我们试图测试2000年在美国接受调查的26,587名女性和6428名男性步行者的中等强度体育锻炼是否影响父母与子女的体重指数和区域肥胖关系。方法：调查问卷提供了自我报告的通常步行距离，身高，体重，腰围以及母亲和父亲的肥胖（1 =瘦，2 =正常，3 =超重和4 =非常超重）。回归分析用于检验父母肥胖对步行者体重指数和腰围的贡献是否随步行而减少。结果：在最久坐的人群中（步行<1.5 km / d），父母平均肥胖是步行者体重指数和腰围的重要决定因素（女性：P <10（-15）;男性：P <10（ -13））。较大的步行距离显着降低了父母平均肥胖对步行者体重指数（女性：P <10（-10）;男性P = 0.003）和腰围（女性：P <10（-6）;男性）的影响。 P = 0.01）。与大多数久坐的女性助行器相比，父母肥胖对体重指数的影响降低了36％，对腰围降低了41％（男性分别降低了36％和46％）。结论：这些结果表明中等强度的体育锻炼以剂量依赖的方式减弱了总肥胖和区域肥胖的遗传。
展开▼
