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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Smoking cessation and COPD mortality among Japanese men and women: The JACC study
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Smoking cessation and COPD mortality among Japanese men and women: The JACC study

机译：日本男女吸烟戒烟和COPD死亡率：JACC研究

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摘要

Objective: To investigate an effect of smoking cessation on chronic obstructive pulmonary disease (COPD) mortality in Asians. Methods: The data was obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 41465 Japanese men and 52662 Japanese women aged 40-79. years who had no history of COPD, asthma, other chronic lung diseases, cardiovascular disease or cancer were followed between 1988 and 2008. Results: During median 18-year of follow-up, there were 285 (251 men and 34 women) documented deaths from COPD. Multivariable-adjusted hazard ratios with 95% confidence intervals of COPD death were 4.46 (2.72-7.29) and 9.26 (4.19-20.5), respectively for current male and female smokers when compared to never smokers. Compared with current smokers, the multivariable HRs for 5-9. years and 10. years or more smoking cessation prior to baseline were 0.44 (0.22-0.87) and 0.36 (0.22-0.58) in men, respectively while the HR for never smokers was 0.30 (0.16-0.57). There were an insufficient number of COPD deaths in women to clarify this association. Conclusion: Smoking cessation for ten years or more prior to enrollment reverses the excess risk of COPD mortality to a level similar to that observed among never smokers in men.
机译：目的：研究戒烟对亚洲人慢性阻塞性肺疾病（COPD）死亡率的影响。方法：数据来自日本癌症风险评估协作研究（JACC研究）。 40-79岁的年龄在41465名日本男性和52662名日本女性。在1988年至2008年之间随访了无COPD，哮喘，其他慢性肺部疾病，心血管疾病或癌症病史的前几年。结果：在中位随访18年中，有285例（251例男性和34例女性）死亡来自COPD。与从未吸烟者相比，目前吸烟的男性和女性吸烟者的COPD死亡置信区间为95％的多变量调整风险比分别为4.46（2.72-7.29）和9.26（4.19-20.5）。与目前的吸烟者相比，多变量HR为5-9。男性在基线之前的11年和10年或更长时间戒烟分别为0.44（0.22-0.87）和0.36（0.22-0.58），从未吸烟者的HR为0.30（0.16-0.57）。妇女中COPD死亡人数不足以阐明这种关联。结论：入学前戒烟十年或以上可使COPD死亡的额外风险逆转至与从未吸烟者中观察到的水平相似的水平。

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