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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk.
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No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk.

机译:在高风险的预期随访的中国人群中,重复内镜筛查对胃癌死亡率没有影响。

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BACKGROUND: Gastric cancer (GC) is the leading cause of cancer deaths in China. Our study prospectively evaluated the impact of repeated endoscopic screens on GC mortality in a high-risk population in China. METHODS: Between 1989 and 1999, a population-based gastroscopic screening was conducted in 4,394 residents of Linqu County, China, a region with the highest rates of GC worldwide. Residents ages 35 to 64 years received initial gastroscopies with biopsies in 1989. Repeated endoscopies were performed in 1994 and 1999. Cancer occurrences and deaths were actively monitored throughout the entire period until July 2000. Mortality from GC was compared with expected values based on mortality rates obtained for Linqu in the 1990-1992 Chinese Cancer Mortality Survey. RESULTS: Between March 1989 and July 2000, 39,303 person-years were accumulated; 85 new GCs occurred, 29 (34.5%) were in early stage. Fifty-eight cases (68%) were identified at one of the screens. The number of observed deaths from GC (37) was close to the expected (36.8). The standardized mortality ratio was 1.01 (95% CI 0.72-1.37) for the entire cohort, 1.13 (95% CI 0.77-1.57) for males, and 0.65 (95% CI 0.26-1.32) for females. CONCLUSIONS: Despite high population coverage with repeated screens, no reduction in GC mortality was observed in this high-risk population in China. Copyright 2002 American Health Foundation and Elsevier Science.
机译:背景:胃癌(GC)是中国癌症死亡的主要原因。我们的研究前瞻性地评估了重复内镜筛查对中国高危人群GC死亡率的影响。方法:在1989年至1999年之间,对中国临qu县的4394名居民进行了基于人群的胃镜检查,该地区是全球GC率最高的地区。 35至64岁的居民于1989年接受了首次胃镜检查,并于1994年和1999年进行了内镜检查。在2000年7月之前的整个期间,都对癌症的发生和死亡进行了积极监测。将GC死亡率与基于死亡率的预期值进行了比较是从1990-1992年中国癌症死亡率调查中获得的临for县人。结果:在1989年3月至2000年7月之间,累积了39,303人年。发生了85个新的GC,早期阶段有29个(34.5%)。在其中一个屏幕上发现了58例(68%)。 GC观察到的死亡人数(37)与预期的(36.8)接近。整个队列的标准死亡率为1.01(95%CI 0.72-1.37),男性为1.13(95%CI 0.77-1.57),女性为0.65(95%CI 0.26-1.32)。结论:尽管通过反复筛查获得了较高的人群覆盖率,但在中国这一高危人群中,GC死亡率并未降低。版权所有2002美国健康基金会和Elsevier Science。

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