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首页> 外文会议>International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) >Environmental and Genetic Risk Analysis for Gastric Cancer in a Chinese Population
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Environmental and Genetic Risk Analysis for Gastric Cancer in a Chinese Population

机译：中国人群胃癌的环境和遗传风险分析

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摘要

A 1∶1 case-control study was accomplished in Nanjing, Jiangsu Province, China. A conditional-logistic regression model was used to determine environmental and genetic risk factors among 374 cases of gastric cancer patients and controls. The environmental risk factors of gastric cancer in the Nanjing area are family history of tumor, tobacco smoking, consumption of pickled food, engorgement after hunger, irregular dietary habits，and lack of fruit intake. The genetic risk factors are genetic polymorphisms of CYP2E1, NAT2M1, NAT2M2, XRCC1,and IL-1B. The results suggest that genetic polymorphisms and environmental risk factors play co-operating roles in the development of gastric cancer.
机译：在中国江苏省南京市完成了1∶1病例对照研究。条件对数回归模型用于确定374例胃癌患者和对照中的环境和遗传危险因素。南京地区胃癌的环境危险因素是肿瘤的家族史，吸烟，食用腌制食品，饥饿后食欲不振，饮食习惯不规律以及水果摄入不足。遗传危险因素是CYP2E1，NAT2M1，NAT2M2，XRCC1和IL-1B的遗传多态性。结果表明，遗传多态性和环境危险因素在胃癌的发展中起着协同作用。

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