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首页> 外文期刊>Journal of toxicology and environmental health, Part A >Analysis and Estimates of the Attributable Riskfor Environmental and Genetic Risk Factors in GastricCancer in a Chinese Population
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Analysis and Estimates of the Attributable Riskfor Environmental and Genetic Risk Factors in GastricCancer in a Chinese Population

机译：中国人群胃癌环境和遗传危险因素的归因风险分析与估计

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摘要

Development of gastric cancer is a multistage, multifactorial process. This study determined the population attributable risk for environmental and genetic risk factors in development of gastric cancer. A 1:1 cancer case-control study was undertaken in Nanjing, Jiangsu Province, China. A conditional-logistic regression model was used to determine environmental and genetic risk factors and calculate attributable risk (AR%) for each environmental and genetic risk factor in gastric cancer. In addition, the summary attributable risk (sAR) for all of the risk factors among 503 cases of gastric cancer patients and controls was determined. The environmental risk factors for gastric cancer in the Nanjing area were family history of tumor, consumption of pickled food, engorgement after hunger, irregular dietary habits, and lack of fruit intake. The genetic risk factors included the following genotypes: CYP2E1 wild, NAT2 Ml mutation, NAT2 slow-acetylators, XRCC1 194 mutation, MTHFR A1298C mutation, and IL-1B mutation. Combining environmental and genetic risk factors, sAR was 76.34%. Data suggest that genetic polymorphisms and environmental risk factors play concurrent roles in the development of gastric cancer. The results of this study indicate preventive strategies to avoid development of gastric cancer based on identified genetic polymorphisms and control of environmental risk factors.
机译：胃癌的发展是一个多阶段，多因素的过程。这项研究确定了人群归因于胃癌发展的环境和遗传风险因素的风险。在中国江苏省南京市进行了1：1癌症病例对照研究。使用条件逻辑回归模型确定环境和遗传风险因素，并计算每种环境和遗传风险因素在胃癌中的归因风险（AR％）。此外，还确定了503例胃癌患者和对照组中所有危险因素的归因归因风险（sAR）。南京地区胃癌的环境危险因素是肿瘤的家族史，食用腌制食品，饥饿后食欲不振，饮食习惯不规律以及水果摄入不足。遗传危险因素包括以下基因型：CYP2E1野生型，NAT2 M1突变，NAT2慢乙酰化剂，XRCC1 194突变，MTHFR A1298C突变和IL-1B突变。结合环境和遗传危险因素，sAR为76.34％。数据表明，遗传多态性和环境危险因素在胃癌的发展中同时起着作用。这项研究的结果表明，基于已确定的遗传多态性和对环境危险因素的控制，可以避免胃癌发展的预防策略。

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