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首页> 外文期刊>Proceedings of the Nutrition Society >The potential role of epigenetic responses to diet in ageing.
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The potential role of epigenetic responses to diet in ageing.

机译：在饮食中表观遗传反应的潜在作用。

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Epigenetic changes may be causal in the ageing process and may be influenced by diet, providing opportunities to improve health in later life. The aim of this review is to provide an overview of several areas of research relevant to this topic and to explore a hypothesis relating to a possible role of epigenetic effects, mediated by sirtuin 1, in the beneficial effects of dietary restriction, including increased lifespan. Epigenetic features of ageing include changes in DNA methylation, both globally and at specific loci, which differ between individuals. A major focus of research on dietary influences on epigenetic status has been on nutrition in utero, because the epigenome is probably particularly malleable during this life-course window and because epigenetic marking by early exposures is a compelling mechanism underlying effects on lifelong health. We explore the potential of diet during adulthood, including the practice of dietary restriction, to affect the epigenetic architecture. We report progress with respect to deriving data to support our hypothesis that sirtuin 1 may mediate some of the effects of dietary restriction through effects on DNA methylation and note observations that resveratrol affects DNA methylation and other epigenetic features. Disentangling cause and effect in the context of epigenetic change and ageing is a challenge and requires better understanding of the underlying mechanisms and also the development of more refined experimental tools to manipulate the epigenetic architecture, to facilitate hypothesis-driven research to elucidate these links and thus to exploit them to improve health across the full life-course through dietary measures.
机译：表观遗传的变化可能是衰老过程中的原因，并且可能受到饮食的影响，从而为以后的生活提供了改善健康的机会。这篇综述的目的是概述与该主题相关的几个研究领域，并探讨一个与表观遗传学作用（可能由Sirtuin 1介导）在饮食限制（包括延长寿命）的有益作用中可能起的作用有关的假说。衰老的表观遗传学特征包括全局和特定位点的DNA甲基化变化，个体之间存在差异。饮食对表观遗传状态影响的研究重点一直放在子宫内营养上，因为表观基因组在这一生命历程中可能特别具有延展性，并且由于通过早期暴露进行表观遗传标记是潜在的引诱机制对终身健康的影响。我们探索成年期饮食的潜力，包括饮食限制的做法，以影响表观遗传结构。我们报告了有关数据的进展，以支持我们的假设，即sirtuin 1可能通过对DNA甲基化的影响来介导饮食限制的某些影响，并注意到白藜芦醇会影响DNA甲基化和其他表观遗传特征的观察结果。在表观遗传的变化和衰老的背景下，要弄清因果关系是一个挑战，需要更好地了解其潜在机制，还需要开发更多精炼的实验工具来操纵表观遗传结构，以促进假设驱动的研究以阐明这些联系，从而通过饮食手段来利用它们改善整个生命过程中的健康。

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