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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >Computational aspects in mechanical modeling of the articular cartilage tissue
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Computational aspects in mechanical modeling of the articular cartilage tissue

机译：关节软骨组织机械建模的计算方面

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摘要

This review focuses on the modeling of articular cartilage (at the tissue level), chondrocyte mechanobiology (at the cell level) and a combination of both in a multiscale computation scheme. The primary objective is to evaluate the advantages and disadvantages of conventional models implemented to study the mechanics of the articular cartilage tissue and chondrocytes. From monophasic material models as the simplest form to more complicated multiscale theories, these approaches have been frequently used to model articular cartilage and have contributed significantly to modeling joint mechanics, addressing and resolving numerous issues regarding cartilage mechanics and function. It should be noted that attentiveness is important when using different modeling approaches, as the choice of the model limits the applications available. In this review, we discuss the conventional models applicable to some of the mechanical aspects of articular cartilage such as lubrication, swelling pressure and chondrocyte mechanics and address some of the issues associated with the current modeling approaches. We then suggest future pathways for a more realistic modeling strategy as applied for the simulation of the mechanics of the cartilage tissue using multiscale and parallelized finite element method.
机译：这篇综述着重于多尺度计算方案中关节软骨（组织水平），软骨细胞力学生物学（细胞水平）的建模以及两者的结合。主要目的是评估用于研究关节软骨组织和软骨细胞力学的常规模型的优缺点。从最简单的单相材料模型到更复杂的多尺度理论，这些方法已被广泛用于关节软骨建模，并为关节力学建模，解决和解决有关软骨力学和功能的众多问题做出了重要贡献。应该注意的是，当使用不同的建模方法时，专注性很重要，因为模型的选择限制了可用的应用程序。在这篇综述中，我们讨论了适用于关节软骨某些机械方面（例如润滑，溶胀压力和软骨细胞力学）的常规模型，并解决了与当前建模方法相关的一些问题。然后，我们提出了一种更现实的建模策略的未来途径，该策略可用于使用多尺度并行化有限元方法模拟软骨组织的力学。

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