No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.

Jonsson EG; Jamra RA; Schumacher J; Flyckt L; Edman G; Forslund K; Mattila Evenden M; Rylander G; Asberg M; Bjerkenstedt L; Wiesel FA; Propping P; Cichon S; Nothen MM; Sedvall GC

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No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.

机译：多巴胺β-羟化酶基因的推定功能启动子变异与精神分裂症之间没有关联。

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SUMMARY: OBJECTIVE Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia.METHODS Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant.RESULTS No significant allele or genotype differences were found.CONCLUSIONS The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.

机译：摘要：目的儿茶酚胺传递的干扰已与精神分裂症有关。多巴胺β-羟化酶在去甲肾上腺素能细胞中催化多巴胺向去甲肾上腺素的转化。我们试图研究多巴胺β-羟化酶基因（DBH）的推定功能启动子多态性与精神分裂症的关系。方法关于DBH -1021，分析了无关的精神分裂症患者（n = 155）和对照组（n = 436）。结果未发现明显的等位基因或基因型差异。结论本研究结果不支持DBH基因在瑞典人群的精神分裂症中有重大参与。

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来源
《Psychiatric genetics》 |2003年第3期|共4页
作者
Jonsson EG; Jamra RA; Schumacher J; Flyckt L; Edman G; Forslund K; Mattila Evenden M; Rylander G; Asberg M; Bjerkenstedt L; Wiesel FA; Propping P; Cichon S; Nothen MM; Sedvall GC;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Schizophrenia; Genes; Dopamine; Relationship by association; Hydroxylases; 精神分裂症; 基因; 多巴胺; 羟化酶类;

机译：Schizophrenia;Genes;Dopamine;Relationship by association;Hydroxylases;精神分裂症;基因;多巴胺;羟化酶类;

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1. No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia. [J] . Jonsson EG, Jamra RA, Schumacher J, Psychiatric genetics . 2003,第3期

机译：多巴胺β-羟化酶基因的推定功能启动子变异与精神分裂症之间没有关联。
2. Genetically engineered dopamine beta-hydroxylase gene promoters with better PHOX2-binding sites drive significantly enhanced transgene expression in a noradrenergic cell-specific manner. [J] . Hwang DY, Hwang MM, Kim HS, Molecular therapy: the journal of the American Society of Gene Therapy . 2005,第1期

机译：具有更好的PHOX2结合位点的基因工程多巴胺β-羟化酶基因启动子以去甲肾上腺素细胞特异性方式驱动转基因表达显着增强。
3. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. [J] . Chen Y, Zhang K, Wen G, American Journal of Hypertension . 2011,第1期

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6. Association between putative functional variants in the PSMB9 gene and risk of melanoma - re-analysis of published melanoma genome-wide association studies [O] . Ji Qian, Hongliang Liu, Sheng Wei, -1

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No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.

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