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首页> 外文期刊>Psychiatric genetics >Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender.
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Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender.

机译：NEO人格量表（修订版）与血清素转运蛋白基因相关的老年人多态性区域之间的关联：抑郁症和性别的影响。

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OBJECTIVE The short variant of the serotonin transporter gene-linked functional polymorphic region (5-HTTLPR) has been associated with personality traits related to anxiety, hostility, and depression. We attempted to replicate findings suggesting a positive relation between the short allele variant of 5-HTTLPR and Neuroticism, and a negative association between the short allele variant and Agreeableness.METHODS Participants in the present study were 103 geriatric depressed patients and 99 non-depressed age matched controls. Depression status and gender were examined as potential modifiers of the association between 5-HTTLPR and personality.RESULTS Neuroticism was associated with allele frequency such that individuals with the short variant of the allele (ss or sl, group S) were significantly lower on Neuroticism ( <0.04) compared with individuals with the long allele variant (group L), a pattern opposite to that of previous reports. The association did not vary by clinical group (depressed or controls)but was conditional on gender ( <0.01): the mean Neuroticism for males in group S was 48.2, whereas the mean Neuroticism for males in group L was 55.9; and the mean Neuroticism for females did not differ by allele group. In the total sample, Agreeableness was not associated with allele frequency; however, there was a significant allele groupxclinical groupxgender interaction ( <0.01).CONCLUSIONS The present findings failed to replicate prior work suggesting that the short variant of the 5-HTTLPR allele is associated with higher Neuroticism and lower Agreeableness.
机译：目的5-羟色胺转运蛋白基因相关的功能性多态性区域（5-HTTLPR）的短变异与焦虑，敌意和抑郁相关的人格特征有关。我们试图复制发现，表明5-HTTLPR的短等位基因变异与神经质之间存在正相关，而短的等位基因变异与愉悦性之间呈负相关。方法本研究的参与者为103例老年抑郁症患者和99例非抑郁症患者匹配的控件。研究人员将抑郁状态和性别作为5-HTTLPR与人格之间联系的潜在调节剂。 <0.04）与具有长等位基因变体的个体（L组）相比，这种模式与以前的报道相反。该关联性随临床组（抑郁或对照）的不同而不同，但取决于性别（<0.01）：S组男性的平均神经质为48.2，而L组男性的平均神经质为55.9。女性的平均神经质在等位基因组中没有差异。在总样本中，“可喜度”与等位基因频率没有关系。然而，存在显着的等位基因组x临床组x性别相互作用（<0.01）。结论目前的发现未能重复先前的工作，这表明5-HTTLPR等位基因的短变异与较高的神经质和较低的愉快度有关。

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